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Category:Primary Adaptive Immunity Deficiencies (view source)

Revision as of 13:53, 12 August 2010

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===Deficiencies of Adaptive Immunity===
 
===Deficiencies of Adaptive Immunity===
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====Equine Severe Combined Immune Deficiency (Equine SCID)====
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====[[Equine Severe Combined Immune Deficiency]] ====
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*Autosomal recessive
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*Occurs in 2-3% of Arabian foals
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*Defect in DNA-dependent protein kinase gene
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**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR)
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*No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]
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*Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time)
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*Foals usually die from bronchopneumonia
      
====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)====
 
====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)====
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*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
 
*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
 
*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
 
*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
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[[Category:Primary Adaptive Immunity Deficiencies]]
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[[Category:To Do - Blood]]
 
====Selective [[IgA]] deficiency of German Shepherd Dogs====
 
====Selective [[IgA]] deficiency of German Shepherd Dogs====
 
*Poorly understood
 
*Poorly understood
 
*Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
 
*Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
 
*[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease
 
*[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease
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[[Category:Primary Adaptive Immunity Deficiencies]]
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[[Category:To Do - Blood]]
 
====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds====
 
====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds====
 
*Unknown aetiology
 
*Unknown aetiology
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**E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|[[IgA]]]]
 
**E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|[[IgA]]]]
 
**E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]]
 
**E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]]
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[[Category:Primary Adaptive Immunity Deficiencies]]
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[[Category:To Do - Blood]]
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[[Category:Primary Immunodeficiency]]
 
[[Category:Primary Immunodeficiency]]
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