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Created page with 'thumb|right|200px|Coccidioidomycosis spherule histopathology - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath *''Coc…'
[[Image:Coccidioidomycosis.jpg|thumb|right|200px|Coccidioidomycosis spherule histopathology - Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath]]
*''Coccidioides immitis''
*Ocurs in the soil
**Respiratory infections
**Most commonly seen following dust storms
*Occurs in arid regions
**E.g. South West USA and Mexico
*Non-contageous, systemic mycosis
*Affects dogs, cattle, sheep and humans
*Mainly affects the [[Lungs - Anatomy & Physiology|lungs]]
**Dissemination can occur to other organs
*Causes nodule or granuloma formation
**Localised
**Gross lesions resemble [[Mycobacteria spp.#Bovine tuberculosis|Tb]] in cattle as are usually seen in the bronchial and mediastinal [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and occasionally [[Lungs - Anatomy & Physiology|lungs]]
**Dissemination can occur, especially in primates and dogs, to the [[Lungs - Anatomy & Physiology|lungs]], [[Liver - Anatomy & Physiology|liver]], [[Spleen - Anatomy & Physiology|spleen]], [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|brain]] and [[Bones and Cartilage - Anatomy & Physiology|bones]]
*Thick-walled spherules in tissue
**Large sporangia burst leaving 'ghost' spherules
*Saprophytic phase consists of coarse, septate, branching hyphae which fragment into thick-walled, barrel-shaped arthrospores which alternate with empty cells
**Stained by Lactose Phenol Cotton Blue
*Grows on Sabouraud's Dextrose agar and Blood agar
**Flat, moist colonies which develop a coarse, cotton-like aerial mycelium which varies from white to brown in colour
*Complement fixation test, latex agglutination and immunodiffusion tests can all be used
**A positive skin test indicates exposure
[[Category:Systemic_Mycoses]]
*''Coccidioides immitis''
*Ocurs in the soil
**Respiratory infections
**Most commonly seen following dust storms
*Occurs in arid regions
**E.g. South West USA and Mexico
*Non-contageous, systemic mycosis
*Affects dogs, cattle, sheep and humans
*Mainly affects the [[Lungs - Anatomy & Physiology|lungs]]
**Dissemination can occur to other organs
*Causes nodule or granuloma formation
**Localised
**Gross lesions resemble [[Mycobacteria spp.#Bovine tuberculosis|Tb]] in cattle as are usually seen in the bronchial and mediastinal [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and occasionally [[Lungs - Anatomy & Physiology|lungs]]
**Dissemination can occur, especially in primates and dogs, to the [[Lungs - Anatomy & Physiology|lungs]], [[Liver - Anatomy & Physiology|liver]], [[Spleen - Anatomy & Physiology|spleen]], [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|brain]] and [[Bones and Cartilage - Anatomy & Physiology|bones]]
*Thick-walled spherules in tissue
**Large sporangia burst leaving 'ghost' spherules
*Saprophytic phase consists of coarse, septate, branching hyphae which fragment into thick-walled, barrel-shaped arthrospores which alternate with empty cells
**Stained by Lactose Phenol Cotton Blue
*Grows on Sabouraud's Dextrose agar and Blood agar
**Flat, moist colonies which develop a coarse, cotton-like aerial mycelium which varies from white to brown in colour
*Complement fixation test, latex agglutination and immunodiffusion tests can all be used
**A positive skin test indicates exposure
[[Category:Systemic_Mycoses]]