Cytology Q&A 06

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A six-year-old female spayed DSH cat presented for chronic weight loss and a recent history of vomiting and severe lethargy. Physical examination revealed pale, icteric mucous membranes. The temperature was 38°C (100.4°F) and pulse and respiration rates were slightly increased. Abdominal palpation and radiographs revealed diffuse hepatomegaly. Examination of a peripheral blood smear indicated RBC shape abnormalities including severe acanthocytosis. Abnormal biochemistry values were: AST = 150 U/l (ref. = 2–36 U/l); ALT = 350 U/l (ref. = 6–80 U/l); ALP = 135 U/l (ref. = 2–43 U/l); bilirubin = 68 μmol/l (ref. = 0–3.4 μmol/l). An FNA of the liver was obtained and a smear made (Wright–Giemsa, ×25).


Question Answer Article
Explain the abnormal RBC shape and the biochemistry abnormalities. Link to Article
Describe the cytological findings, and give your cytological interpretation. Link to Article
List the differentials for your diagnosis, and discuss treatment options. Link to Article



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