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Ethylene Glycol Toxicity (view source)
Revision as of 20:06, 10 November 2010
, 20:06, 10 November 2010no edit summary
*increased urea and creatinine, hyperkalaemia,
*increased urea and creatinine, hyperkalaemia,
===Ultrasonography===
===Ultrasonography===
*Accumulation of Calcium Oxalate Crystals in kidney result in renal hyperechogenicity upon ultrasound examination <ref>'''Textbook of Veterinary Internal Medicine''', (Seventh Edition), ''Ettinger and Feldman''; p1968 </ref>.
*Accumulation of Calcium Oxalate Crystals in kidney result in renal hyperechogenicity upon ultrasound examination <ref name=''multiples''>'''Textbook of Veterinary Internal Medicine''', (Seventh Edition), ''Ettinger and Feldman''; p1968 </ref>.
===Biopsy====
*Needle or surgical wedge biopsy of kidney <ref name=''multiples''>'''Textbook of Veterinary Internal Medicine''', (Seventh Edition), ''Ettinger and Feldman''; p1968 </ref>.
===Pathology===
===Pathology===
==Treatment==
==Treatment==
* Ethanol
*4-methylpyrazole
Ethylene Glycol is a weak acid. Therefore in order to increase the rate of renal clearance sodium bicarbonate can be administered to dogs. Intravenous administration of sodium bicarbonate at a concentration of 1-2 mmol/kg every 3 to 6 hours achieves sufficient alkalinisation of the urine.<ref>'''Canine Medicine and Therapeutics''' (Fourth Edition, 1998),''Blackwell Science'', p1049 </ref>
Ethylene Glycol is a weak acid. Therefore in order to increase the rate of renal clearance sodium bicarbonate can be administered to dogs. Intravenous administration of sodium bicarbonate at a concentration of 1-2 mmol/kg every 3 to 6 hours achieves sufficient alkalinisation of the urine.<ref>'''Canine Medicine and Therapeutics''' (Fourth Edition, 1998),''Blackwell Science'', p1049 </ref>