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Follicles - Anatomy & Physiology (view source)
Revision as of 18:17, 16 July 2008
, 18:17, 16 July 2008→Follicular Development
*The oocyte had developed a thick translucent glycoprotein layer called the Zona Pellucida.
*The oocyte had developed a thick translucent glycoprotein layer called the Zona Pellucida.
*Oocyte surrounded by two or more layers of follicular cuboidal cells. These cells differenciate into the inner Granulosa cells and outer Theca cells.
*Oocyte surrounded by two or more layers of follicular cuboidal cells. These cells differenciate into the inner Granulosa cells and outer Theca cells.
4. Tertiary Follicles
4. Tertiary/Antral Follicles
*The innermost cells of the Granulosa layer become firmly attached to the Zona Pellucida and are known as the Corona Radiata. The outermost Granulosa cells become attached to the basement membrane surrounding them and become known as the Theca Folliculi.
*The innermost cells of the Granulosa layer become firmly attached to the Zona Pellucida and are known as the Corona Radiata. The outermost Granulosa cells become attached to the basement membrane surrounding them and become known as the Theca Folliculi.
*Granulosa cells secrete fluid which accumulates within the follicle forming an Antrum.
*Theca cells become organised into Theca Interna and Theca Externa layers. The Theca Interna layer cells differenciate into steroidogenic cells produce the Androgen Androsteinedione in response to the Gonadotrophin Luteinising hormone (LH).
*Theca Cell layer becomes vascularised.
*Granulosa cells become responsive to Follicle Stimulating Hormone (FSH) and start producing 17β-Oestrodiol and small amounts of Inhibin and Progesterone.
'''Dominant Follicle'''
*Only a single Dominant follicle forms with each wave of folliculogenesis.
==function==
==function==