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** Encoded by a gene on the X chromosome, rare deficiencies in FoxP3 are characterised by autoimmunity, primarily towards gut tissue, the thyroid, pancreative beta-cells and the skin. Sufferers are unable to produce regulatory T cells and the only known treatment is a bone marrow transplant from a MHC-identical sibling.
 
** Encoded by a gene on the X chromosome, rare deficiencies in FoxP3 are characterised by autoimmunity, primarily towards gut tissue, the thyroid, pancreative beta-cells and the skin. Sufferers are unable to produce regulatory T cells and the only known treatment is a bone marrow transplant from a MHC-identical sibling.
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==[[Immune tolerance flashcards - Wikiblood|Immune tolerance flashcards]]==
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==Test yourself with the Immunology Flashcards==
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[[Immune tolerance flashcards - Wikiblood|Immune tolerance flashcards]]
    
[[Category:Immunology]]
 
[[Category:Immunology]]
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