Immunoglobulin D

Shortened to IgD

IgD

IgD - B. Catchpole, RVC 2008

Overview

IgD is present in ruminants, pigs, dogs and rodents but has not been identified in horses, cats, rabbits and chickens. It is mainly expressed on the surface of B-cells i.e. it is never secreted.

Structure

IgD is Y-shaped. In rodents, it has two heavy chain constant regions, whereas other mammals have three. IgD has a long hinge region and no disulfide bonds.

Function

IgD is only expressed in association with IgM. It is important in B-cell development.

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^{Immunoglobulins: Immunoglobulin A, Immunoglobulin D, Immunoglobulin E, Immunoglobulin G & Immunoglobulin M}