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→Leishmania
*Present in southern Europe, Africa, Asia and South America
*Present in southern Europe, Africa, Asia and South America
*Can cause both cutaneous and visceral diseases
'''Recognition'''
*Ovoid shaped
*Possesses a rod-shaped kinetoplast
*Has a rudimentry flagellum which does not project beyond the cell margin
*After the amastigote has transformed into a promastigote inside the [[Biting Flies#Psychodidae|sand fly]], the kinetoplast is situated in the posterior of the body
'''Life Cycle'''
'''Life Cycle'''
*Invades [[Macrophage|macrophages]] and reverts to amastigote
*Invades [[Macrophage|macrophages]] and reverts to amastigote
*Multiplies by binary fission
'''Pathogenesis'''
'''Pathogenesis'''
*Cutaneous form
*Cutaneous form
**Produces areas of ulceration on pinnae of ears
**Produces areas of ulceration on pinnae of [[The Ear - Anatomy & Physiology|ears]], eyelids or on the [[Lips - Anatomy & Physiology|lips]]
*Visceral form causes chronic wasting condition
*Visceral form causes chronic wasting condition
**Intermittent fever
**Intermittent fever
**Generalised lymphadenopathy
**Generalised lymphadenopathy
*Long periods of remission followed by the onset of clincial signs are not uncommon in infections
*Involved in [[Parasitic skin infections - Pathology#Protozoa|skin infections]]
*Involved in [[Parasitic skin infections - Pathology#Protozoa|skin infections]]