Liver Necrosis

Causes

Hepatocytic necrosis can occur following severe metabolic disturbances, toxic substances, nutritional deficiencies and through the action of micro-organisms.
Liver cell necrosis has been classified on an anatomic basis with reference to the distribution of the lesion.

Random foci (focal)

Microscopic foci of necrosis is not related to any particular part of the liver lobule and can be due to a variety of insults such as, systemic viral, bacterial and parasitic infections and as a result of bacteria being absorbed from the gut.
Examples include

• • Equine herpes virus infection; necrosis found in aborted foetuses.
  • Salmonellosis; necrosis found in the liver of calves due to the S. dublin serotype.
  • Toxoplasmosis (miliary necrosis), which is found in affected dogs and cats.

Zonal necrosis

Zonal necrosis is necrosis ocurring mainly in a part of the lobule and further subdivided according to whether the lesions are situated centrally, peripherally, or in the mid-zone of the lobule:

Periacinar (centrilobular)

This is the most common type of zonal necrosis and occurs mainly due to the fact that the hepatocytes in this zone are furthest away from the incoming blood supply and are therefore less oxygenated and relatively anoxic. They are reported to contain the greatest number of enzymes responsible for metabolising sunstances to more toxic metabolites capable of killing the hepatocytes. Therefore hypoxic states and toxic substances predominate in this type of necrosis, although some viral conditions also cause this nerosis, such as Infectious Canine Hepatitis. This is a highly infectious disease of young dogs which is pread by urine. It is now rare due to vaccination in the UK.

Midzonal=

Midzonal necrosis is rare and is mainly seen in pigs with alfatoxicosis. It is also seen in humans suffering from 'Yellow Fever'.

Periportal (centroacinar)

Centroacinar necrosis is also rare. This has been seen in cases of phosphorous poisoning.

Massive necrosis

This occurs when there is necrosis of a complete acinus or an even larger area of tissue. It encompasses large areas of liver cells comprising many lobules (complete acinus or several acini) and sometimes involving almost the whole organ.
It can occur is some cases of ICH infection or carbon tetrachloride poisoning, with the severity of the injury replacing the zonal pattern.

Subacute cytolytic necrosis

This is a condition in the dog, of which the aetiology is entirely unknown. Clinical symptoms include acute abdominal pain, collapse and invariably jaundice. Pathology shows the Liver is normal or reduced in size and that there is severe necrosis.

Hepatosis dietica

This is a similar condition to subacute cytolytic necrosis, but it occurs in rapidly growing pigs. It is thought to be related to diet and occurs in pigs fed on large quantities of grain concentrates, poor quality or low quantity protein supplements. This results in nutritional deficiencies of selenium and Vitamin E, and probably amino acids. It is thought to be triggered by stress.

References

Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition), Elsevier Science.
Ettinger, S.J, Feldman, E.C. (2005) Textbook of Veterinary Internal Medicine (6th edition, volume 2), W.B. Saunders Company.
Fossum, T. W. et. al. (2007) Small Animal Surgery (Third Edition), Mosby Elsevier.
Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition), Mosby Elsevier.

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Liver Pathology Flashcards