Malignant Catarrhal Fever Virus
Revision as of 18:03, 29 October 2008 by Bepocock (talk | contribs) (New page: {{unfinished}} {{toplink |linkpage =Viruses |linktext =VIRUSES |sublink1=Herpesviridae |subtext1=HERPESVIRUSES |pagetype =Bugs }} <br> ====Hosts==== *Reservoir species: wildebeest, sheep...)
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Hosts
- Reservoir species: wildebeest, sheep, each transferring different forms of the virus
- Innocuous to reservoir hosts
- Dead end hosts: cows, kudu, some deer
Pathogenesis
- Sporadically induce a fatal over-active T cell division, where virus encodes anti-apoptotic protein in dead-end host
- Latent infection
- Virus excretion increased during periparturient period
- Clinical signs in cattle:
- Necrotising lesions in upper respiratory tract, gingiva and eye
- Lymphocyte proliferation progresses in lymphoid tissue and blood until death
Control
- Wildebeest should not be stocked in zoos where possible
- Sheep and deer should be housed separately