Neutropenia

• Neutropenia is a reduction in numbers of neutrophils circulating in the blood.

• Occurs with:
  • Infections caused by Gram-negative organisms.
    • Cause by the effects of their endotoxins.
  • Factors that destroy their formation in the bone marrow.
  • For example
    • Radiation
    • Toxins affecting bone marrow functions
      • E.g. Bracken
    • Some viruses
      • E.g. Parvovirus and Infectious Canine Hepatitis
    • Tumours that replace or displace normal bone marrow.