Difference between revisions of "Telangiectasis"

Latest revision as of 14:36, 6 May 2011

Also known as: Plum-pudding Liver

Introduction

Telangiectasis ('plum-pudding liver') is a condition of the liver affecting cattle, sheep, poultry and horses. The lesions are characterised by focal dilatation and congestion of the hepatic sinusoids. All animals may be affected by the lesions but they are more commonly seen in older animals. There is little clinical significance to the disease but affected animals are a significant cause of direct economic loss due to carcass condemnation at slaughter.

Pathogenesis

Various aetiologies for the condition have been suggested. It has been widely proposed that telangiectasis occurs due to ischaemic necrosis of the liver relating to a number underlying causes. These include thromboembolism, pregnancy, abdominal tympany and bacterial infection with Fusobacterium necrophorum. Other theories include high levels of vitamin A, metabolic disturbances and neoplastic or immune-mediated processes.

Following slaughter, animals with mildly affected livers may be passed for food following trimming but severely affected carcasses must be condemned.

Pathology

Lesions commonly develop at the parietal portion of the liver or at the periphery. They usually appear as irregularly-shaped red depressions on the surface of the liver that extend into the parenchyma and consist of dilated sinusoids filled with blood and lined with epithelium. Livers containing a few lesions are commonly seen in young animals.

On histopathology, hepatocytes appear swollen and degenerate with intracytoplasmic vacuoles and dilated sinusoids. The dilated sinusoids are filled with erythrocytes and fibrin strands and leucocytes are occasionally seen. The hepatic parenchyma surrounding the lesions is frequently normal.

Literature Search

Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).

Telangiectasis publications

References

Gracey, J. F., Collins, D. S., Huey, R. J. (1999) Meat Hygiene Elsevier Health Sciences
Hubbert, W. T. (1996) Food Safety and Quality Assurance: foods of animal origin Wiley-Blackwell

@@ Line 1: / Line 1: @@
-{{unfinished}}
+Also known as: '''''Plum-pudding Liver
+==Introduction==
+Telangiectasis ('plum-pudding liver') is a condition of the liver affecting cattle, sheep, poultry and horses. The lesions are characterised by focal dilatation and congestion of the hepatic sinusoids. All animals may be affected by the lesions but they are more commonly seen in older animals. There is little clinical significance to the disease but affected animals are a significant cause of direct economic loss due to carcass condemnation at slaughter.
-Telangiectasis is a condition of the liver affecting cattle, sheep poultry and horses. The lesions are characterised by focal dilatation and congestion of the hepatic sinusoids.
+==Pathogenesis==
+Various aetiologies for the condition have been suggested. It has been widely proposed that telangiectasis occurs due to ischaemic necrosis of the liver relating to a number underlying causes. These include thromboembolism, pregnancy, abdominal tympany and bacterial infection with ''[[Fusobacterium necrophorum]]''. Other theories include high levels of vitamin A, metabolic disturbances and neoplastic or immune-mediated processes.
-All animals may be affected by the lesions but they are more commonly seen in older animals. There is little clinical significance to the disease but affected animals are a significant cause of direct economic loss due to carcass condemnation at slaughter.
+Following slaughter, animals with mildly affected livers may be passed for food following trimming but severely affected carcasses must be condemned.
-Various aetiologies for the condition have been suggested. It has been proposed that telangiectasis is caused by ischaemic necrosis relating to a number underlying causes including pregnancy, abdominal tympany and bacterial infection with ''Fusobacterium necrophorum''. Other theories include a neoplastic or immune-mediated process.
+==Pathology==
+Lesions commonly develop at the parietal portion of the liver or at the periphery. They usually appear as irregularly-shaped red depressions on the surface of the liver that extend into the parenchyma and consist of dilated sinusoids filled with blood and lined with epithelium. Livers containing a few lesions are commonly seen in young animals.
+On histopathology, hepatocytes appear swollen and degenerate with intracytoplasmic vacuoles and dilated sinusoids. The dilated sinusoids are filled with erythrocytes and fibrin strands and leucocytes are occasionally seen. The hepatic parenchyma surrounding the lesions is frequently normal.
-Following slaughter, animals with mildly affected livers may be passed for food following trimming but severely affected carcasses must be condemned.
+==Literature Search==
+[[File:CABI logo.jpg|left|90px]]
+Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
+<br><br><br>
+[http://www.cabdirect.org/search.html?it=any&q2=plum+pudding+liver&q1=Telangiectasis&calendarInput=yyyy-mm-dd&occuring1=title&show=all&rowId=1&rowId=2&rowId=3&options1=AND&options2=OR&options3=AND&occuring3=freetext&occuring2=title&publishedend=yyyy&la=any&publishedstart=yyyy&fq=sc%3A%22ve%22&y=13&x=37 Telangiectasis publications]
+== References ==
+*Gracey, J. F., Collins, D. S., Huey, R. J. (1999) '''Meat Hygiene''' ''Elsevier Health Sciences''
+*Hubbert, W. T. (1996) '''Food Safety and Quality Assurance: foods of animal origin''' ''Wiley-Blackwell''
-[[Category:Liver - Circulatory Disturbances]]
+{{review}}
-[[Category:To_Do_-_Clinical]]
+[[Category:Liver_-_Circulatory_Disturbances]] [[Category:Liver_Diseases_-_Cattle]] [[Category:Liver_Diseases_-_Sheep]] [[Category:Alimentary_Diseases_-_Birds]] [[Category:Liver_Diseases_-_Horse]] [[Category:Brian Aldridge reviewing]]