Difference between revisions of "Type II Hypersensitivity"
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2. [[Complement - WikiBlood|Complement]] mediated lysis | 2. [[Complement - WikiBlood|Complement]] mediated lysis | ||
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** [[Autoimmune diseases - WikiClinical#1. Immune Mediated Haemolytic Anaemia (IMHA)|Immune mediated haemolytic anaemia]] | ** [[Autoimmune diseases - WikiClinical#1. Immune Mediated Haemolytic Anaemia (IMHA)|Immune mediated haemolytic anaemia]] | ||
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** Blood transfusion reaction | ** Blood transfusion reaction | ||
** [[Materno-fetal immunity - WikiBlood#Alloimmune haemalytic anaemia of the newborn|Haemolytic disease of new born (Rhesus disease in humans and neonatal isoerythrolysis in foals and kittens)]] | ** [[Materno-fetal immunity - WikiBlood#Alloimmune haemalytic anaemia of the newborn|Haemolytic disease of new born (Rhesus disease in humans and neonatal isoerythrolysis in foals and kittens)]] | ||
Revision as of 12:54, 12 June 2010
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Introduction
Production of IgM or IgG to cell surface antigens or extracellular matrix proteins.
Mechanism
"Neutralisation" blockade of receptors:
- Antibodies attach to receptors, which prevents other molecules attaching.
- For example in myasthenia gravis antibodies attach to acetylcholine receptors which in turn prevents acetylcholine from attaching to the receptor and thus muscle contraction of that cell does not occur.
Immunological attack on target cells, destroying them by (see diagram):
1. Antibody dependent cell cytotoxicity (ADCC)
2. Complement mediated lysis
- Self RBC antigen:
- Foreign RBC:
- Blood transfusion reaction
- Haemolytic disease of new born (Rhesus disease in humans and neonatal isoerythrolysis in foals and kittens)
- RBC parasite:
- Feline infectious anaemia (Mycoplasma haemofelis)
3. Phagocytosis