Author, Donkey, Bureaucrats, Administrators
53,803
edits
Changes
Jump to navigation
Jump to search
no edit summary
Line 1:
Line 1:
−
Also known as: '''''Lymphosarcoma'''''
+Also known as: '''''Lymphosarcoma — Malignant Lymphoma'''''
==Introduction==
==Introduction==
Line 231:
Line 231:
[[Category:Neoplasia]]
[[Category:Neoplasia]]
[[Category:Splenic Neoplasia]]
[[Category:Splenic Neoplasia]]
+
+
+
+===== Classification=====
+
+* '''Cytological classification'''.
+** Well differentiaed (lymphocytic)
+*** The malignant cells represent normal lymphocytes, although in excessive numbers.
+** Poorly differentiated (lymphoblastic).
+*** The malignant cells represent atypical lymphocytic cells with lymphoblastic characteristics.
+* '''Tumour distribution'''
+** Nodular/ follicular.
+*** A well organised pattern of slow growth.
+*** No metastasis.
+*** Are of the B-lymphocyte type.
+** Diffuse.
+*** Result in effacement of normal lymphoid architecture by a very homogeneous population of lymphoid cells.
+* '''Anatomical classification'''
+** Thymic.
+** Only the [[Thymus - Anatomy & Physiology|thymus]].
+** Alimentary.
+*** Gut and associated lymphoid tissue.
+** Multicentric.
+*** Widespread involvement of lymph nodes.
+** Cutaneous lymphoma.
+*** Usually presents as generalised skin disease, but is a malignant transformation of T cells with a propensity for pithelial sites
+* '''Type of lymphocyte'''
+** T-cell.
+** B-cell.
+** NK-cell.
+* '''Time scale'''
+** Acute.
+** Chronic.
+
+=====Prevalence=====
+
+* Order of prevalence in UK: cats, dogs, cattle, pigs and sheep.
+** In the cat and ox, viral agents have been identified as the causal agents.
+* Lymphoma is one of the prevalent neoplasms in the dog.
+** 80% of cases affect the 5 to 11 year old age group.
+** The incidence is about 28 per 100,000 dogs.
+** Blood of affected dogs shows neither a relative nor absolute increase in the number of lymphocytes until the late stages of the disease.
+*** When this stage is reached, poorly differentiated cells may appear in the blood.
+* FeLV is an important cause of lymphoma in the cat.
+** 70% of cats with lymphoma will test positive for FeLV.
+** FeLV also causes a number of non-neoplastic diseases.
+*** Anaemia.
+*** Leukopaenia.
+*** Thymic atrophy.
+* Cattle suffer both lymphosarcoma and leukosis in a variety of cytological forms.
+** Bovine lymphoma is caused by [[Bovine Leukaemia Virus]] (BLV).
+*** A retrovirus.
+*** There is a juvenile form of bovine lymphoma seen in young cattle which is not associated with BLV.
+
+=====Species Differences=====
+
+* The form of the disease may differe between species.
+* '''Feline'''
+** Alimentary.
+*** Affects the mesenteric lymph nodes, intestine, [[Liver - Anatomy & Physiology|liver]], spleen , and potentially the kidney.
+** Thymic
+*** Presents as a thymis mass, also in the mediastinal lymph nodes.
+*** The pleural lymph nodes and the [[Liver - Anatomy & Physiology|liver]] may potentially be affected.
+** Multicentric
+*** Found in the peripheral and deep lymph nodes, [[Liver - Anatomy & Physiology|liver]] and spleen.
+**** The kidney may sometimes be affected.
+** Renal
+*** The kidney and other abdominal organs are affected.
+** Leukaemic
+*** Affects the bone marrow alone.
+*** This form is rare.
+* '''Canine'''
+** Alimentary.
+*** Affects the mesenteric lymph nodes, pancreatic lymph nodes, intestine, and potentially the [[Liver - Anatomy & Physiology|liver]].
+** Thymic.
+*** Thymic and mediastinal masses.
+** Multicentric.
+*** Affects the peripheral and deep lymph nodes, [[Liver - Anatomy & Physiology|liver]], spleen and kidney.
+* '''Bovine'''
+** Thymic.
+*** Mainly affects adults.
+*** Thymic and mediastinal masses.
+*** Some lymph nodes are also affected.
+** Multicentric.
+*** Mainly affects yopung adults.
+*** Affects the peripheral and deep lymph nodes, spleen, [[Liver - Anatomy & Physiology|liver]] and kidney.
+* '''Equine'''
+** Takes mainly an alimentary form.
+** Can rarely be cutaneous.
+* '''Porcine'''
+** Mainly multicentric.
+*** Lymph nodes, [[Liver - Anatomy & Physiology|liver]], spleen.
+* '''Ovine'''
+** Uncommon.
+** May be multicentric or thymic.