Changes

Along with the actions of the fragments mentioned above, Ca fragments C3a, C4a and C5a, and Cb fragment C2b also form a chemotactic response. This brings [[Neutrophils|neutrophils]] to the area of complement activation through the process of [[Neutrophils|extravasation]] through the increase in cell adhesion molecules on the endothelium and an increase in vascular permeability; and chemotaxis which is the direct cellular movement. The fragments can also cause [[Mast Cells|mast cell]] and [[Basophils|basophil]] degranulation. These therefore induce '''acute inflammation'''.

Along with the actions of the fragments mentioned above, Ca fragments C3a, C4a and C5a, and Cb fragment C2b also form a chemotactic response. This brings [[Neutrophils|neutrophils]] to the area of complement activation through the process of [[Neutrophils|extravasation]] through the increase in cell adhesion molecules on the endothelium and an increase in vascular permeability; and chemotaxis which is the direct cellular movement. The fragments can also cause [[Mast Cells|mast cell]] and [[Basophils|basophil]] degranulation. These therefore induce '''acute inflammation'''.

===Alternative Pathway===

===Alternative Pathway===

===Mannose Binding-Lectin Pathway===

===Mannose Binding-Lectin Pathway===

<p>Lectins are proteins that bind carbohydrates e.g. collectins. They bind carbohydrates that have a terminal mannose residue and are called mannose-binding lectins.

<p>Lectins are proteins that bind carbohydrates e.g. collectins. They bind the carbohydrates as they have a terminal mannose residue, and are therefore called '''mannose-binding lectins'''. These are secreted by the liver into plasma.  

*Secreted by the liver into plasma.  

* The action of lectin binding to carbohydrate activates plasma-associated proteases called mannose-binding lectin associated proteases (MASPs)

** These act on C4 and C2 in the same way as C1 esterase, and on C3 in much the same manner as C3 convertase</p>

The main action of lectin binding to carbohydrate is to activate plasma-associated proteases called mannose-binding lectin associated proteases (MASPs). These act on C4 and C2 in the same way as C1 esterase, and on C3 in much the same manner as C3 convertase</p>

==Membrane Attack Complex==

==Membrane Attack Complex==