Changes

==Membrane Attack Complex==

==Membrane Attack Complex==

[[Image:LH Complement lysis.png|thumb|200px|right|'''Membrane Attack Complex''']]

[[Image:LH Complement lysis.png|thumb|200px|right|'''Membrane Attack Complex''']]

This is the lytic pathway of complement function and can be initiated via either C3bB¯b3b or C4b2¯a3b.  

This is the lytic pathway of complement function and can be initiated via either C3b¯Bb¯3b or C4b¯2a¯3b.  

#Split C5 into:

These split C5 into C5a which is pro-inflammatory, and C5b, the first molecule of the MAC (very short-lived and biologically active)

#*C5a is pro-inflammatory.

#*C5b the first molecule of the MAC (very short-lived and biologically active)

#C5b rapidly attaches to cell surfaces and binds to one C6 molecule

C5b rapidly attaches to cell surfaces and binds to one C6 molecule. The C5bC6 then binds to one C7 molecule and can then bind to the cell membrane via the C7. This then enables the binding of one C8 molecule. It is the C8 which inserts into the cell membrane and enables C9 to bind. These polymerize within the cell membrane (1-16 C9 molecules) resulting in a small pore being formed which causes cell lysis by osmotic shock.

#C5bC6 binds one C7 molecule

#*C5bC6 binds to cell membrane via C7

#C5b67 binds one C8 molecule

#*C8 inserts into the cell membrane

# C9 molecules bind and polymerize within the cell membrane (1-16 C9 molecules)</p>

<p>The polymerization of C9 results in a small pore being formed which causes cell lysis by osmotic shock.</p>

==Complement Inhibitors==

==Complement Inhibitors==