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Equine Peyer's Patches - Horse Anatomy (view source)
Revision as of 17:21, 28 November 2012
, 17:21, 28 November 2012Created page with "{{unfinished}} thumb|250px|right|<p>'''Diagram: Peyer's patch'''</p><sup>©Nottingham Uni 2008</sup> ==Introduction== Peyer’s pa..."
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[[Image:LH Ileal Peyer's Patch Diagram.jpg|thumb|250px|right|<p>'''Diagram: Peyer's patch'''</p><sup>©Nottingham Uni 2008</sup>]]
==Introduction==
Peyer’s patches are lymphoid tissues found in the wall of the [[Alimentary System - Horse Anatomy#Small Intestine|small intestine]]. They are part of the [[Regional Lymphoid Tissue - Anatomy & Physiology|mucosal-associated lymphoid tissues (MALT)]] and more specifically the gut-associated lymphoid tissue (GALT). Although nodules of lymphatic tissue are found throughout the intestines in the [[Alimentary System - Horse Anatomy#Small Intestine|small intestine]], larger collections of nodules exist and these are referred to as Peyer’s patches. They may act as a [[:Category:Primary Lymphoid Tissue|primary lymphoid tissue]] in the horse.
==Structure==
Peyer’s patches are located in the lamina propria and submucosa of [[Alimentary System - Horse Anatomy#Small Intestine|small intestine]] and may be distinguishable by the lack of villi covering them. The patches are regions of concentrated [[Lymphocytes#B cells|B lymphocyte]] follicles covered in a ‘dome’ of a specialised follicle associated epithelium (FAE) which consists of follicle associated enterocytes and M (microfold or multifold) cells.
===M cells===
M cells transport antigens from the intestinal lumen to the lymphocytes. Their luminal surface is folded and takes up antigens from the intestine via endocytosis and transports them to the extracellular space on their basal surface where the antigen is processed by antigen presenting cells.
===Histology===
<center><gallery perrow="3">
Image:LH_Ileal_Peyer's_Patch_Low_Histology.jpg|<p>'''Intetsine w/Peyer's patch'''</P> <sup>©RVC 2008</sup>
Image:LH_Ileal_Peyer's_Patch_Histology.jpg|<p>'''Peyer's patch'''</P> <sup>©RVC 2008</sup>
Image:peyers patches.jpg|<p>'''Peyer's patches'''</p><sup>Courtesy of BioMed Archive</sup></gallery></center>
==Function==
Peyer’s patches have a role in maturation and differentiation of immature B lymphocytes. Antigens are presented to the [[Lymphocytes#B cells|B lymphocytes]] in the follicle which causes the [[Lymphocytes#B cells|B cells]] to become committed to [[Immunoglobulin A|IgA]] synthesis.
[[Image:LH Ileal Peyer's Patch Diagram.jpg|thumb|250px|right|<p>'''Diagram: Peyer's patch'''</p><sup>©Nottingham Uni 2008</sup>]]
==Introduction==
Peyer’s patches are lymphoid tissues found in the wall of the [[Alimentary System - Horse Anatomy#Small Intestine|small intestine]]. They are part of the [[Regional Lymphoid Tissue - Anatomy & Physiology|mucosal-associated lymphoid tissues (MALT)]] and more specifically the gut-associated lymphoid tissue (GALT). Although nodules of lymphatic tissue are found throughout the intestines in the [[Alimentary System - Horse Anatomy#Small Intestine|small intestine]], larger collections of nodules exist and these are referred to as Peyer’s patches. They may act as a [[:Category:Primary Lymphoid Tissue|primary lymphoid tissue]] in the horse.
==Structure==
Peyer’s patches are located in the lamina propria and submucosa of [[Alimentary System - Horse Anatomy#Small Intestine|small intestine]] and may be distinguishable by the lack of villi covering them. The patches are regions of concentrated [[Lymphocytes#B cells|B lymphocyte]] follicles covered in a ‘dome’ of a specialised follicle associated epithelium (FAE) which consists of follicle associated enterocytes and M (microfold or multifold) cells.
===M cells===
M cells transport antigens from the intestinal lumen to the lymphocytes. Their luminal surface is folded and takes up antigens from the intestine via endocytosis and transports them to the extracellular space on their basal surface where the antigen is processed by antigen presenting cells.
===Histology===
<center><gallery perrow="3">
Image:LH_Ileal_Peyer's_Patch_Low_Histology.jpg|<p>'''Intetsine w/Peyer's patch'''</P> <sup>©RVC 2008</sup>
Image:LH_Ileal_Peyer's_Patch_Histology.jpg|<p>'''Peyer's patch'''</P> <sup>©RVC 2008</sup>
Image:peyers patches.jpg|<p>'''Peyer's patches'''</p><sup>Courtesy of BioMed Archive</sup></gallery></center>
==Function==
Peyer’s patches have a role in maturation and differentiation of immature B lymphocytes. Antigens are presented to the [[Lymphocytes#B cells|B lymphocytes]] in the follicle which causes the [[Lymphocytes#B cells|B cells]] to become committed to [[Immunoglobulin A|IgA]] synthesis.