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| + | ==Phases of Gastric Secretion== |
| + | |
| + | ===Cephalic=== |
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| + | *Unconditioned reflex |
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| + | *Sight, smell, taste of food |
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| + | *Vagus nerve (CN X) |
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| + | *[[Endocrine System - Gut - Anatomy & Physiology|Gastrin]] secreted from endocrine cells in pyloric mucosa |
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| + | *Histamine secreted from paracrine action |
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| + | *Increase stomach motility by release of hydrochloric acid and pepsinogen |
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| + | ===Gastric=== |
| + | |
| + | *Chemical and mechanical receptors in stomach |
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| + | *Histamine and gastrin released |
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| + | *Negative feedback loop by sympathomimetic somatostatin released by paracrine method to inhibit gastrin secretion (when pH falls below 3) |
| + | |
| + | ===Intestinal=== |
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| + | *Chyme in the duodenum inhibits acid secretion and motility |
| + | |
| + | *Chyme causes release of secretin, [[Endocrine System - Gut - Anatomy & Physiology|GIP]] and [[Endocrine System - Gut - Anatomy & Physiology|CCK]] |
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| + | ===Pancreatic=== |
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| + | *[[Endocrine System - Gut - Anatomy & Physiology|CCK]], secretin and [[Endocrine System - Gut - Anatomy & Physiology|Gastrin]] |
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| + | *Parasympathetic stimulation during cephalic and gastric phases |
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| + | *Negative feedback from paracrine sympathomimetics (somatostatin and enkephalins) |
| + | |
| + | ===Biliary=== |
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| + | *[[Endocrine System - Gut - Anatomy & Physiology|CCK]] empties [[Gall Bladder - Anatomy & Physiology|gall bladder]] |
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| + | *Secretin stimulates hydrogencarbonate ions from bile duct |
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| + | ===Small Intestinal=== |
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| + | *Succus entericus |
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| + | *Secretin, [[Endocrine System - Gut - Anatomy & Physiology|GIP]] and [[Endocrine System - Gut - Anatomy & Physiology|Gastrin]] |
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| + | *Vagal tone and parasympathomimetic reflex |
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| ==Neuroendocrine Regulation of Feeding== | | ==Neuroendocrine Regulation of Feeding== |