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Created page with "== GLDH Introduction == ''Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe in..."
== GLDH Introduction ==
''Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe insult is required to bring about its release and it is therefore not a sensitive general marker for hepatic disease. However, GLDH has been demonstrated to be a sensitive marker of hepatocellular necrosis in the dog irrespective of its severity.''
=== ''Small Animals'' ===
==== ''Causes of increased GLDH activity'' ====
* ''Hepatocellular necrosis''
* ''Secondary hepatopathies (for example, congestive heart failure and small intestinal pathology)''
==== ''Complementary tests'' ====
''ALT, albumin, bilirubin and bile acids.''
=== ''Equine'' ===
''GLDH has a relatively short half life in the horse (12-14 hours) compared to LDH, [[Aspartate aminotransferase|AST]] and [[Gamma-glutamyltransferase|GGT]]. Elevated levels therefore indicate active hepatocellular damage.''
==== Causes of increased GLDH activity ====
* ''Hepatocellular necrosis''
* ''Enteropathy – common and levels can be quite high''
==== ''Complementary tests'' ====
''[[Aspartate aminotransferase|AST]], [[Gamma-glutamyltransferase|GGT]] (hepatocellular damage) and bile acids (hepatic function).''
== Authors & References ==
[[NationWide Laboratories]]
''Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe insult is required to bring about its release and it is therefore not a sensitive general marker for hepatic disease. However, GLDH has been demonstrated to be a sensitive marker of hepatocellular necrosis in the dog irrespective of its severity.''
=== ''Small Animals'' ===
==== ''Causes of increased GLDH activity'' ====
* ''Hepatocellular necrosis''
* ''Secondary hepatopathies (for example, congestive heart failure and small intestinal pathology)''
==== ''Complementary tests'' ====
''ALT, albumin, bilirubin and bile acids.''
=== ''Equine'' ===
''GLDH has a relatively short half life in the horse (12-14 hours) compared to LDH, [[Aspartate aminotransferase|AST]] and [[Gamma-glutamyltransferase|GGT]]. Elevated levels therefore indicate active hepatocellular damage.''
==== Causes of increased GLDH activity ====
* ''Hepatocellular necrosis''
* ''Enteropathy – common and levels can be quite high''
==== ''Complementary tests'' ====
''[[Aspartate aminotransferase|AST]], [[Gamma-glutamyltransferase|GGT]] (hepatocellular damage) and bile acids (hepatic function).''
== Authors & References ==
[[NationWide Laboratories]]