''Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe insult is required to bring about its release and it is therefore not a sensitive general marker for hepatic disease. However, GLDH has been demonstrated to be a sensitive marker of hepatocellular necrosis in the dog irrespective of its severity.'' | ''Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe insult is required to bring about its release and it is therefore not a sensitive general marker for hepatic disease. However, GLDH has been demonstrated to be a sensitive marker of hepatocellular necrosis in the dog irrespective of its severity.'' |