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== GLDH Introduction ==

== GLDH Introduction ==

''Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe insult is required to bring about its release and it is therefore not a sensitive general marker for hepatic disease. However, GLDH has been demonstrated to be a sensitive marker of hepatocellular necrosis in the dog irrespective of its severity.''

Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe insult is required to bring about its release and it is therefore not a sensitive general marker for hepatic disease. However, GLDH has been demonstrated to be a sensitive marker of hepatocellular necrosis in the dog irrespective of its severity.

=== ''Small Animals'' ===

=== Small Animals ===

==== ''Causes of increased GLDH activity'' ====

==== Causes of increased GLDH activity ====

* ''Hepatocellular necrosis''

* Hepatocellular necrosis

* ''Secondary hepatopathies (for example, congestive heart failure and small intestinal pathology)''

* Secondary hepatopathies (for example, congestive heart failure and small intestinal pathology)

==== ''Complementary tests'' ====

==== Complementary tests ====

''ALT, albumin, bilirubin and bile acids.''

ALT, albumin, bilirubin and bile acids.

=== ''Equine'' ===

=== Equine ===

''GLDH has a relatively short half life in the horse (12-14 hours) compared to LDH, [[Aspartate aminotransferase|AST]] and [[Gamma-glutamyltransferase|GGT]]. Elevated levels therefore indicate active hepatocellular damage.''

GLDH has a relatively short half life in the horse (12-14 hours) compared to LDH, [[Aspartate aminotransferase|AST]] and [[Gamma-glutamyltransferase|GGT]]. Elevated levels therefore indicate active hepatocellular damage.

==== Causes of increased GLDH activity ====

==== Causes of increased GLDH activity ====

* ''Hepatocellular necrosis''

* Hepatocellular necrosis

* ''Enteropathy – common and levels can be quite high''

* Enteropathy – common and levels can be quite high

==== ''Complementary tests'' ====

==== Complementary tests ====

''[[Aspartate aminotransferase|AST]], [[Gamma-glutamyltransferase|GGT]] (hepatocellular damage) and bile acids (hepatic function).''

[[Aspartate aminotransferase|AST]], [[Gamma-glutamyltransferase|GGT]] (hepatocellular damage) and bile acids (hepatic function).

== Authors & References ==

== Authors & References ==

[[NationWide Laboratories]]

[[NationWide Laboratories]]