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<big><center>[[Bones|'''BACK TO BONES''']]</center></big>
−[[Category:Delete]]
+===Changes to normal structure===
+**Damage to periosteum:
+***Invokes a hyperplastic reaction of the inner layer
+***Is painful
+***Exostoses can remodel or remain
+**Lifting of periosteum causes new bone formation below
+**Circumferential incision (e.g. during [[Bones - fractures|fracture]])
+***Longitudinal bone growth results
+***May be only on one side where periosteum is damaged
+****Used by surgeons to treat [[Bones - developmental#Angular limb deformity|angular limb deformities]]
+===Physis (Growth plate)===
+*Site of many '''congenital''' or '''nutritional''' bone diseases in the growing animal
+*'''Open''' in neonates and growing animals
+**Chondrocyte proliferation balances cell maturation and death
+*'''Closes and ossifies''' at maturity
+**Regulated by androgens
+*If growth teporarily stops -> layer of bone seals the growth plate -> moves into metaphysis when growth resumes -> forms '''Harris lines'''