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<big><center>[[Bones|'''BACK TO BONES''']]</center></big>
[[Category:Delete]]
===Changes to normal structure===
**Damage to periosteum:
***Invokes a hyperplastic reaction of the inner layer
***Is painful
***Exostoses can remodel or remain
**Lifting of periosteum causes new bone formation below
**Circumferential incision (e.g. during [[Bones - fractures|fracture]])
***Longitudinal bone growth results
***May be only on one side where periosteum is damaged
****Used by surgeons to treat [[Bones - developmental#Angular limb deformity|angular limb deformities]]
===Physis (Growth plate)===
*Site of many '''congenital''' or '''nutritional''' bone diseases in the growing animal
*'''Open''' in neonates and growing animals
**Chondrocyte proliferation balances cell maturation and death
*'''Closes and ossifies''' at maturity
**Regulated by androgens
*If growth teporarily stops -> layer of bone seals the growth plate -> moves into metaphysis when growth resumes -> forms '''Harris lines'''