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T cell differentiation (view source)
Revision as of 20:08, 3 September 2008
, 20:08, 3 September 2008→Killing Mechanism
* The CTl killing mechanism is initiated by direct CTL-target cell contact.
* The CTl killing mechanism is initiated by direct CTL-target cell contact.
* The cells involved bind by antigen/[[Adaptive Immune System - WikiBlood#Structure and Function of MHC Class I|MHC]]
* The cells involved bind by antigen/[[Adaptive Immune System - WikiBlood#Structure and Function of MHC Class I|MHC]] class I-TcR interaction.
class I-TcR interaction.
** This results in the CTL's intracellular granules becoming localised to the area of contact.
** This results in the CTL's intracellular granules becoming localised to the area of contact.
*** These granules contain most of the molecules responsible for cytotoxicity.
*** These granules contain most of the molecules responsible for cytotoxicity.