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Endocrine effects on the skin - Pathology (view source)
Revision as of 11:53, 29 October 2008
, 11:53, 29 October 2008no edit summary
<p>After telogen the follicle re-enters anagen and the dermal papilla reattaches to the base of the follicle. If the old hair has not already epilated it will be pushed out by the new growing hair.</p>
<p>After telogen the follicle re-enters anagen and the dermal papilla reattaches to the base of the follicle. If the old hair has not already epilated it will be pushed out by the new growing hair.</p>
===Pathogenesis===
===Pathogenesis===
<p>General skin changes (endocrine alopecia) seen with endocrine disease include:
<p>General skin changes ('''endocrine alopecia''') seen with endocrine disease include:
*Hypotrichosis.
*Hypotrichosis.
*Alopecia; usually bilaterally symmetric and non-pruritic.
*Alopecia; usually bilaterally symmetric and non-pruritic.
**Microscopically: telogen follicles, hyperkeratosis and acanthosis or epidermis and follicular infundibulum
**Microscopically: telogen follicles, hyperkeratosis and acanthosis or epidermis and follicular infundibulum
*Castration responsive dermatosis
*'''Castration responsive dermatosis'''
**Mainly involves intact male dogs
**Grossly: fluffy and wool like hair coat, symmetrical alopecia over perineum, thighs, ventral abdomen and thorax, neck; possible hyperpigmentation
**Microscopically: increased nmbe of catagen and telogen hair follicles and flame follicles
**Castration may temporarily remove symptoms
*Superficial necrolytic dermatopathy
*Superficial necrolytic dermatopathy