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, 18:03, 29 October 2008
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{{toplink
|linkpage =Viruses
|linktext =VIRUSES
|sublink1=Herpesviridae
|subtext1=HERPESVIRUSES
|pagetype =Bugs
}}
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====Hosts====
*Reservoir species: wildebeest, sheep, each transferring different forms of the virus
**'''Innocuous''' to reservoir hosts
*Dead end hosts: cows, kudu, some deer
====Pathogenesis====
*Sporadically induce a fatal over-active T cell division, where virus encodes anti-apoptotic protein in dead-end host
*'''Latent''' infection
*Virus excretion increased during periparturient period
*Clinical signs in cattle:
**Necrotising lesions in upper respiratory tract, [[Cavity & Gingiva - Pathology#Malignant Catarrhal Fever|gingiva]] and eye
**Lymphocyte proliferation progresses in lymphoid tissue and blood until death
====Control====
*Wildebeest should not be stocked in zoos where possible
*Sheep and deer should be housed separately