Changes

===Prostaglandin analogues===

===Prostaglandin analogues===

When used in man, prostaglandin El analogues are thought to act by inhibiting gastric acid secretion and enhancing mucosal protection. They have been shown to increase bicarbonate and mucus secretion in man and dogs. Published experimental data demonstrate that PGE analogues protect the gastric mucosa from NSAIDinduced ulceration. Side effects (diarrhoea, abdominal distention bloating) reported in man may also apply to the horse. Anecdotal reports vary with regard to safety.(EGUC)

Synthetic prostaglandin E1 analogues are believed to inihibit gastric acid secretion and enhance mucosal cytoprotection(127 in Sanchez). Misoprostol has been an effective agent in the treatment of human gastric and duodenal ulcers and at 5µg/kg has been shown to increase gastric pH in horses (128 in Sanchez).  Although contraindicated in pregnant mares, Misoprostol may be beneficial for mucosal recovery in the face of flunixin treatment.(129 in Sanchez)

===Gastric prokinetics===

===Gastric prokinetics===