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Innate Immunity Cellular Responses (view source)
Revision as of 15:58, 13 August 2010
, 15:58, 13 August 2010no edit summary
** Blood '''[[Monocytes|monocytes]]''': phagocytose bacteria
** Blood '''[[Monocytes|monocytes]]''': phagocytose bacteria
** Tissue mast cells and '''macrophages''': phagocytose bacteria
** Tissue mast cells and '''macrophages''': phagocytose bacteria
*Effectively, innate cellular response seeks to hold off the infection until the [[Adaptive Immune System - WikiBlood|adaptive]] response can back it up with a more specific attack
*Effectively, innate cellular response seeks to hold off the infection until the [[Adaptive Immune System|adaptive response]] can back it up with a more specific attack
==[[Macrophages|Macrophages]]==
[[Image:Monocytes.jpg|thumb|right|150px|Monocytes - J. Bredl, RVC 2008]]
[[Image:Monocytes.jpg|thumb|right|150px|Monocytes - J. Bredl, RVC 2008]]
*The role of macrophages in Innate Immunity is to act as primary '''phagocytes'''
*The role of macrophages in Innate Immunity is to act as primary '''phagocytes'''
** Chiefly function to replace the various tissue macrophage populations
** Chiefly function to replace the various tissue macrophage populations
==[[Neutrophils|Neutrophils]]==
[[Image:Neutrophil 2.jpg|thumb|right|150px|Neutrophils - J. Bredl, RVC 2008]]
[[Image:Neutrophil 2.jpg|thumb|right|150px|Neutrophils - J. Bredl, RVC 2008]]
* Neutrophils are the principal, highly active '''phagocytes''' in the blood
* Neutrophils are the principal, highly active '''phagocytes''' in the blood
** Their removal from the site after the removal of infection is an important step in the resolution of the lesion
** Their removal from the site after the removal of infection is an important step in the resolution of the lesion
==[[Eosinophils|Eosinophils]]==
[[Image:Eosinophil.jpg|thumb|right|150px|Eosinophil - J. Bredl, RVC 2008]]
[[Image:Eosinophil.jpg|thumb|right|150px|Eosinophil - J. Bredl, RVC 2008]]
* Eosinophils are less common than [[Neutrophils|neutrophils]], and they are not phagocytic
* Eosinophils are less common than [[Neutrophils|neutrophils]], and they are not phagocytic
* Prominent in [[:Category:Allergic Diseases|allergic]] (anaphylactic) reactions
* Prominent in [[:Category:Allergic Diseases|allergic]] (anaphylactic) reactions
==[[Basophils|Basophils]] / [[Mast Cells|Mast Cells]]==
[[Image:Basophil and Lymphocyte.jpg|thumb|right|150px|Basophil - J. Bredl, RVC 2008]]
[[Image:Basophil and Lymphocyte.jpg|thumb|right|150px|Basophil - J. Bredl, RVC 2008]]
* Basophils/mast cells are principally localised at epithelial surfaces
* Basophils/mast cells are principally localised at epithelial surfaces
*** Less than 0.5% circulating leukocytes
*** Less than 0.5% circulating leukocytes
* They have two principal functions:
* They have two principal functions:
*# Induction of [[Inflammation - WikiBlood|acute inflammation]]
*# Induction of [[:Category:Inflammation|acute inflammation]]
*#* Trauma and/ or bacterial infection causes the production of '''cytokines''' by the mast cells that induce a classical acute inflammatory response
*#* Trauma and/ or bacterial infection causes the production of '''cytokines''' by the mast cells that induce a classical acute inflammatory response
*# Response to parasite infection
*# Response to parasite infection