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Text replace - "[[MHC - WikiBlood|" to "[[Major Histocompatability Complexes|"
* Activation of [[Lymphocytes#T cells|T cells]] requires two distinct signals.
* Activation of [[Lymphocytes#T cells|T cells]] requires two distinct signals.
** '''Signal 1'''
** '''Signal 1'''
*** The interaction of the TcR with the antigenic peptide/[[MHC - WikiBlood|MHC]] complex on the antigen presenting cell.
*** The interaction of the TcR with the antigenic peptide/[[Major Histocompatability Complexes|MHC]] complex on the antigen presenting cell.
** '''Signal 2'''
** '''Signal 2'''
*** The interaction of CD28 on the [[Lymphocytes#T cells|T cells]] with its ligand, CD80, on the antigen-presenting cell.
*** The interaction of CD28 on the [[Lymphocytes#T cells|T cells]] with its ligand, CD80, on the antigen-presenting cell.