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Rats (Laboratory) - Pathology (view source)
Revision as of 16:22, 27 August 2010
, 16:22, 27 August 2010→Strains, Stocks and Transgenics
===Strains, Stocks and Transgenics===
===Strains, Stocks and Transgenics===
All rat populations used in research can be included in one of these three groups. Figure 1 is based on a PubMed search of the number of papers using the designated strain or stock for the years 2001-2005 [http://www.isogenic.info/html/rat_strains.html-http://www.isogenic.info/html/rat_strains.html].
All rat populations used in research can be included in one of these three groups. Figure 1 is based on a PubMed search of the number of papers using the designated strain or stock for the years 2001-2005.
The vast majority of work (76%) was done using outbred Sprague-Dawley or Wistar rats. Inbred strains were used on only 12% of occasions. Of the inbred strains, the most widely used was F344 (32.1%), followed by LEW (22.5%). Mutants (=transgenic) were used only in 1% of the studies, reflecting the circumstances explained below.
The vast majority of work (76%) was done using outbred Sprague-Dawley or Wistar rats. Inbred strains were used on only 12% of occasions. Of the inbred strains, the most widely used was F344 (32.1%), followed by LEW (22.5%). Mutants (=transgenic) were used only in 1% of the studies, reflecting the circumstances explained below.