5,582
edits
Changes
Jump to navigation
Jump to search
Normal Mechanisms of Haemostatic Control (view source)
Revision as of 09:24, 29 September 2010
, 09:24, 29 September 2010no edit summary
Line 62:
Line 62:
Following violent stress or injury with severe pain a general hyperfibrinolytic state is produced after widespread or profound clotting where all the circulating fibrinogen is used up. This can also occur on inactivation of endogenous plasminogen inhibitors, for example with patients given salicylates.
Following violent stress or injury with severe pain a general hyperfibrinolytic state is produced after widespread or profound clotting where all the circulating fibrinogen is used up. This can also occur on inactivation of endogenous plasminogen inhibitors, for example with patients given salicylates.
+
+==Other systems involved in haemostasis:==
+
+<p>Activation of the blood coagulation cascade often activates, or is accompanied by the activation of other systems. This appears to be largely the result of activating Factor XII (the Hageman factor) - i.e. the initiation of plasma thromboplastin.</p>
+===Kinin system===
+Usually this system is associated with inflammatory reactions.
+*Inactive kininogen (a 2-globulin fraction of plasma) is activated by plasmin and kallikreins.
+*Increases vascular permeability
+*Increases leucocyte migration
+*May give the pain sensation
+
+===The Complement System===
+[[Complement|The complement system]] is another cascade system where inactive precursors in plasma are triggered by:
+* Bacterial enzymes
+* Antigen-antibody complexes
+* Thrombin
+
==Snake Venoms==
==Snake Venoms==