Difference between revisions of "Immunoglobulin E"

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==Overview==
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<p>Commonly referred to as '''''IgE</p>
[[Image:LH IgE.png|thumb|250px|right|'''IgE''']]
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[[Image:LH IgE.png|thumb|150px|right|'''IgE''']]
[[Image:IgE.jpg|thumb|right|250px|IgE - B. Catchpole, RVC 2008]]
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[[Image:IgE.jpg|thumb|right|150px|IgE - B. Catchpole, RVC 2008]]
 
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<p>Unlike [[IgM]], [[IgG]] and [[IgA]], IgE does not function as a soluble antibody and is found in low levels in blood plasma. Like [[IgA]] it is produced by plasma cells and is mainly localised to mucosal surfaces.</p>
Commonly referred to as ''IgE''.
 
 
 
Unlike [[IgM]], [[IgG]] and [[IgA]], IgE does not function as a soluble antibody, with binding to Fcε receptors required before it can bind to the target antigen, and is found in low levels in blood plasma. Like [[IgA]], it is produced by [[B cell differentiation|plasma cells]] and is mainly localised to mucosal surfaces.
 
 
 
 
==Structure==
 
==Structure==
 
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<p>IgE is Y-shaped with heavy chain type ε, and exists as a monomer.</p>
IgE is Y-shaped with heavy chain type ε, and exists as a monomer.  
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''Note: Janeway <ref>{{citation|initiallast = Janeway|initialfirst = C.A|2last = Travers|2first = P|3last = Walport|3first = M|finallast = Shlomchik|finalfirst = M.J|year = 2005|title = Immunobiology: The immune system in health and disease|ed = 6th |city = New York|pub = Garland Science Publishing|range = 156-157}}</ref> states that IgE has no hinge region whereas Tizard <ref>{{citation|initiallast = Tizard|initialfirst = I.R|year = 2004|title = Veterinary Immunology: An Introduction|ed = 7th|city = Philadelphia|pub = Saunders|range = 148-149}}</ref> indicates that it does.
 
 
''Note: Janeway <ref>{{citation|initiallast = Janeway|initialfirst = C.A|2last = Travers|2first = P|3last = Walport|3first = M|finallast = Shlomchik|finalfirst = M.J|year = 2005|title = Immunobiology: The immune system in health and disease|ed = 6th |city = New York|pub = Garland Science Publishing|range = 156-157}}</ref> states that IgE has no hinge region whereas Tizard <ref>{{citation|initiallast = Tizard|initialfirst = I.R|year = 2004|title = Veterinary Immunology: An Introduction|ed = 7th|city = Philadelphia|pub = Saunders|range = 148-149}}</ref> indicates that it does.''
 
 
 
 
==Production==
 
==Production==
 
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<p>It is produced when Th2 cells stimulate CD40 and produce Il-4 and Il-13 which causes B cell differentiation to plasma cells and class switching to IgE production.</p>
It is produced when T<sub>H</sub>2 cells stimulate CD40 and produce IL-4 and IL-13, which causes B cell differentiation to plasma cells and class switching to IgE production.
 
 
 
 
==Function==
 
==Function==
 
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<p>
IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and [[Basophils|basophils]], causing degranulation when bound to target. It is involved in [[Type I Hypersensitivity|type I hypersensitivity reactions]]. Cross-linking of IgE molecules by antigens, triggers [[Mast Cells|mast cell]] and [[Eosinophil|eosinophil]] degranulation and an inflammatory response. IgE has considerable involvement in producing [[Immunity to Parasites|immunity to parasitic worms]], particularly [[:Category:Nematodes|nematode]] parasites. It may mediate their expulsion or killing via mast cell activity, cytotoxic [[Eosinophils|eosinophils]], [[Macrophages|macrophages]], and so on.
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*IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and basophils, causing degranulation
 
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*It is involved in type I hypersensitivity reactions
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*Cross-linking of IgE molecules by antigen triggers mast cell degranulation and an inflammatory response</p>
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<p>
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*IgE has considerable involvement in producing immunity to parasitic worms and particularly nematode parasites
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**It may mediate their expulsion or killing via mast cell activity, cytotoxic eosinophils, macrophages, and so on</p>
 
==References==
 
==References==
 
<references />
 
<references />
 
<br>
 
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----
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<center><b><sup>[[Immunoglobulins|Immunoglobulins]]: [[Immunoglobulin A|Immunoglobulin A]], [[Immunoglobulin D|Immunoglobulin D]], [[Immunoglobulin E|Immunoglobulin E]], [[Immunoglobulin G|Immunoglobulin G]] & [[Immunoglobulin M|Immunoglobulin M]]</sup></b></center>
  
==Links==
 
 
[[Immunoglobulins|Immunoglobulins]]
 
 
[[Immunoglobulin A|Immunoglobulin A]]
 
 
[[Immunoglobulin D|Immunoglobulin D]]
 
 
[[Immunoglobulin G|Immunoglobulin G]]
 
 
[[Immunoglobulin M|Immunoglobulin M]]
 
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{{Jim Bee 2007}}
 
 
{{OpenPages}}
 
 
[[Category:Immunoglobulins]]
 
[[Category:Immunoglobulins]]
[[Category:A&P Done]]
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[[Category:Image Review]]
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[[Category:To Do - A&P]]

Revision as of 12:19, 4 January 2011


Commonly referred to as IgE

IgE
IgE - B. Catchpole, RVC 2008

Unlike IgM, IgG and IgA, IgE does not function as a soluble antibody and is found in low levels in blood plasma. Like IgA it is produced by plasma cells and is mainly localised to mucosal surfaces.

Structure

IgE is Y-shaped with heavy chain type ε, and exists as a monomer.

Note: Janeway [1] states that IgE has no hinge region whereas Tizard [2] indicates that it does.

Production

It is produced when Th2 cells stimulate CD40 and produce Il-4 and Il-13 which causes B cell differentiation to plasma cells and class switching to IgE production.

Function

  • IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and basophils, causing degranulation
  • It is involved in type I hypersensitivity reactions
  • Cross-linking of IgE molecules by antigen triggers mast cell degranulation and an inflammatory response

  • IgE has considerable involvement in producing immunity to parasitic worms and particularly nematode parasites
    • It may mediate their expulsion or killing via mast cell activity, cytotoxic eosinophils, macrophages, and so on

References

  1. Janeway, C.A., Travers, P., Walport, M. and Shlomchik, M.J. (2005) Immunobiology: The immune system in health and disease. 6th ed. New York: Garland Science Publishing. pp.156-157.
  2. Tizard, I.R. (2004) Veterinary Immunology: An Introduction. 7th ed. Philadelphia: Saunders. pp.148-149.



Immunoglobulins: Immunoglobulin A, Immunoglobulin D, Immunoglobulin E, Immunoglobulin G & Immunoglobulin M