Difference between revisions of "Blastomycosis"

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(Created page with '*North America **Most common in the North-Central and South-Eastern states *Caused by ''Blastomyces dermatitidis'' *Widespread in soil *Respiratory infection *Lesions start i…')
 
 
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*Treatment:
 
*Treatment:
 
**[[Antifungal Drugs#Polyene Antifungals|Amphotericin B]]
 
**[[Antifungal Drugs#Polyene Antifungals|Amphotericin B]]
**[[Antifungal Drugs#The Azoles|Imidazoles]][[Category:Systemic_Mycoses]]
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**[[Antifungal Drugs#The Azoles|Imidazoles]]
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*Caused by [[Yeast-like fungi|''Blastomyces dermatitidis'']]
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*Occurs mainly in the Americas, Middle East and Africa, occasionally in Europe
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*Mainly in young dogs, occasionally other species
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*Can involve almost any tissue after spread from lungs
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*Gross lesions:
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**[[Granulomatous Pneumonia|Granulomatous pneumonia]]
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*Microscopic lesions:
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**Yeast fungi with thich walls in nodules with macrophages, [[Neutrophils|neutrophils]] and giant cells
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==Test yourself with the Systemic Mycoses Flashcards==
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[[Systemic_Mycoses_-_Flashcards#Blastomycosis|Blastomycosis Flashcards]]
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[[Category:Systemic_Mycoses]]
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[[Category:To_Do_-_Fungi]]
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[[Category:Respiratory Fungal Infections]]

Latest revision as of 18:34, 19 February 2011

  • North America
    • Most common in the North-Central and South-Eastern states
  • Caused by Blastomyces dermatitidis
  • Widespread in soil
  • Respiratory infection
  • Lesions start in the lungs
    • Haematogenous dissemination
    • Can be found in lesions in the eyes, brain, bones and genitalia
    • Fatal if not treated
  • Lesions are also found on the skin
  • These may ulcerate
  • Granulomatous nodules
  • Affects mainly dogs (and humans)
    • Can affect cats, horses, dolphins, ferrets and sealions but is rare in these species
  • Microscopically:
    • Large, spherical, thick-walled cells
    • Single buds connected to a mother cell by a wide base
    • Double contoured effect of cells
  • Grows on Sabauraud's Dextrose and Blood agar
    • On Sabauraud's Dextrose colonies appear moist and grey with a white cotton-like mycelium which turns tan, brown and then black
      • Septate hyphae
      • Small, oval/pyriform conidia
      • Older cultures have thickened walls
    • On Blood agar colonies are creamy in colour, waxy and wrinkled
      • Thick-walled budding yeast cells can be seen
  • Diagnosis:
    • Complement fixation test
    • Falling antibody titres indicate a poor prognosis
    • ELISA and counterimmunoelectrophoresis can also be used


  • Caused by Blastomyces dermatitidis
  • Occurs mainly in the Americas, Middle East and Africa, occasionally in Europe
  • Mainly in young dogs, occasionally other species
  • Can involve almost any tissue after spread from lungs
  • Gross lesions:
  • Microscopic lesions:
    • Yeast fungi with thich walls in nodules with macrophages, neutrophils and giant cells

Test yourself with the Systemic Mycoses Flashcards

Blastomycosis Flashcards