Bronchiectasis

Bronchiectasis (Image sourced from Bristol Biomed Image Archive with permission)

Bronchiectasis (Image sourced from Bristol Biomed Image Archive with permission)

• Permanent, abnormal saccular or cylindrical dilation of bronchi
• Accumulation of exudate within the lumen and partial rupture of bronchial walls
• Sequel to chronic bronchitis as result of an unresolved persistent bronchopneumonia
• Chronic inflammation within the bronchial mucosa and wall -> release of proteolytic enzymes from neutrophils and macrophages -> destruction of supporting structures in the bronchial walls (eg: cartilage, connective tissue) -> weakens the bronchial walls and damages lining mucosal epithelial cells and their cilia (damage to mucociliary escalator)
• Atelectasis in the surrounding lung parenchyma results in increased inspiratory effort and increased intrathoracic negative pressure during inspiration
• The weakened bronchial walls are less able to 'resist' the negative pressure and therefore dilate excessively.
• With time this dilation becomes permanent as a viscous cycle of exudate pooling in the lumen and increased contact of the bronchial walls with the leukocytes further weakens the bronchial walls.
• Most severe in cattle (complete lobular septation and lack of collateral ventilation), least severe in dogs (good colateral ventilation), also seen in sheep, goats and pigs
• In very severe cases, the bronchial wall is completely destroyed and unrecognisable - an abscess

Test yourself with the Bronchi and Bronchioles Pathology Flashcards

Bronchi and Bronchioles Pathology Flashcards