Difference between revisions of "Skin Immunologic - Pathology"
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− | + | {{review}} | |
+ | |||
+ | {{toplink | ||
+ | |backcolour = FFCCCC | ||
+ | |linkpage =Integumentary System - Pathology | ||
+ | |linktext =Integumentary System | ||
+ | |maplink = Integumentary System (Content Map) - Pathology | ||
+ | |pagetype =Pathology | ||
+ | }} | ||
+ | <br> | ||
+ | |||
+ | ==General== | ||
+ | |||
+ | *Classification: | ||
+ | **Hypersensitivity - response to normally harmless substances | ||
+ | **Auto-immune - antobodies or T-cells reactive against self-antigens | ||
+ | *Mostly involves mixture of types described below | ||
+ | |||
+ | |||
+ | |||
+ | ==Autoimmune reactions== | ||
+ | |||
+ | ===[[Bullous Pemphigoid]]=== | ||
+ | |||
+ | |||
+ | |||
+ | ===[[Canine Dermatomyositis]]=== | ||
+ | |||
+ | |||
+ | ===[[Systemic Lupus Erythematosus]]=== | ||
+ | |||
+ | *'''Systemic (SLE)''' | ||
+ | **Multiple organs involved | ||
+ | **Cats, dogs, horses | ||
+ | **Immune dysregulation: | ||
+ | ***Damaged T-cell suppressor function, either primary deficiency or antibody mediated | ||
+ | ***Cytokine dysregulation | ||
+ | ***Resulting B-cell hyperactivity -> antibodies to self antigens -> antigen-antibody complexes deposited in various tissues -> Type III hypersensitivity | ||
+ | **Lesions localised or generalised | ||
+ | **Erythema, alopecia, depigmentation, crusting and scaling, ulceration | ||
+ | **Microscopically: lymphohistiocytic interface dermatitis, thickened basement membrane, vasculitis, subepidermal vesicles, basal cell degeneration | ||
+ | *'''Discoid''' | ||
+ | **Milder variant of systemic | ||
+ | **Depigmentation, erythema, scaling, erosions, ulceration, crusting | ||
+ | **Usually involves nasal planum, dorsum of muzzle, occasionally pinnae, lips, oral mucosa or periocular area | ||
+ | **Microscopically: lichenoid interface dermatitis, often with lymphocytes, plasma cells, basal cell degeneration, loss of pigment | ||
+ | |||
+ | [[Category:Integumentary System - Autoimmune Reactions]] | ||
+ | |||
+ | ===[[Pemphigus]]=== |
Revision as of 16:52, 22 February 2011
This article has been peer reviewed but is awaiting expert review. If you would like to help with this, please see more information about expert reviewing. |
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General
- Classification:
- Hypersensitivity - response to normally harmless substances
- Auto-immune - antobodies or T-cells reactive against self-antigens
- Mostly involves mixture of types described below
Autoimmune reactions
Bullous Pemphigoid
Canine Dermatomyositis
Systemic Lupus Erythematosus
- Systemic (SLE)
- Multiple organs involved
- Cats, dogs, horses
- Immune dysregulation:
- Damaged T-cell suppressor function, either primary deficiency or antibody mediated
- Cytokine dysregulation
- Resulting B-cell hyperactivity -> antibodies to self antigens -> antigen-antibody complexes deposited in various tissues -> Type III hypersensitivity
- Lesions localised or generalised
- Erythema, alopecia, depigmentation, crusting and scaling, ulceration
- Microscopically: lymphohistiocytic interface dermatitis, thickened basement membrane, vasculitis, subepidermal vesicles, basal cell degeneration
- Discoid
- Milder variant of systemic
- Depigmentation, erythema, scaling, erosions, ulceration, crusting
- Usually involves nasal planum, dorsum of muzzle, occasionally pinnae, lips, oral mucosa or periocular area
- Microscopically: lichenoid interface dermatitis, often with lymphocytes, plasma cells, basal cell degeneration, loss of pigment