Difference between revisions of "Joint Response to Injury"
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m (Text replace - "[[Disorders of Cell Growth - Pathology" to "[[Cell Growth Disorders") |
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*Synovial membranes respond by: | *Synovial membranes respond by: | ||
**Villous hypertrophy | **Villous hypertrophy | ||
| − | ***+/- | + | ***+/- synovitis |
**Hyperplasia | **Hyperplasia | ||
Revision as of 16:30, 3 March 2011
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Causes of injury
- Trauma
- Instability
- Lubrication failure
- Infectious organisms
- Immune-mediated disease
Reaction to injury
- Articular cartilage has limited ability to regenerate
- Superficial defects are long standing
- Chondrocyte hyperplasia is ineffective at filling the defect
- Non-painful
- Defects reaching subchondral bone
- Filled with vascular fibroous tissue undergoing metaplasia into cartilage
- Painful
- Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface
- Eburnation - loss of articular cartilage -> exposure of subchondral bone -> becomes dense and polished
- Superficial defects are long standing
- Synovial membranes respond by:
- Villous hypertrophy
- +/- synovitis
- Hyperplasia
- Villous hypertrophy