Difference between revisions of "Theileria"
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{{Taxobox | {{Taxobox | ||
| − | |name = | + | |name = Theileria spp |
|kingdom = Protista | |kingdom = Protista | ||
|sub-kingdom = | |sub-kingdom = | ||
| − | |phylum = | + | |phylum =Protozoa |
|super-class = | |super-class = | ||
|class = | |class = | ||
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|sub-family = | |sub-family = | ||
|genus = Theileria | |genus = Theileria | ||
| − | |species = | + | |species = Theileria parva and others |
}} | }} | ||
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==Introduction== | ==Introduction== | ||
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''Theileria'' species are a group of '''[[Protozoa | protozoan]]''' pathogens causing severe '''lymphatic proliferative disease''' in cattle. | ''Theileria'' species are a group of '''[[Protozoa | protozoan]]''' pathogens causing severe '''lymphatic proliferative disease''' in cattle. | ||
| − | '''''T. parva''''' is the species of most veterinary importance, affecting cattle in Central and Eastern Africa | + | '''''T. parva''''' is the species of most veterinary importance, affecting cattle in Central and Eastern Africa. |
Other species cause significant economic losses in the Mediterranean, Middle East and Northern Africa. | Other species cause significant economic losses in the Mediterranean, Middle East and Northern Africa. | ||
==Lifecycle== | ==Lifecycle== | ||
| − | ''Theileria'' are transmitted via the | + | [[Image:Theileria parva life cycle.jpg|thumb|right|200px|''Theileria parva'' Life Cycle Diagram - Dennis Jacobs & Mark Fox RVC]] |
| + | ''Theileria'' are transmitted via the ''Haemaphysalis'' and ''Rhipicephalus'' and ''Dermacentor'' species of '''[[Ticks | tick]] vectors'''. | ||
'''Sporozoites''' enter '''mononuclear''' cells of the host and develop into '''trophozoites''' and multinucleate '''schizonts''' by '''asexual''' reproduction. This process stimulates proliferation of the host cells, allowing further multiplication of the parasite. The local '''[[Lymph Nodes - Anatomy & Physiology|lymph nodes]]''' are first infected. | '''Sporozoites''' enter '''mononuclear''' cells of the host and develop into '''trophozoites''' and multinucleate '''schizonts''' by '''asexual''' reproduction. This process stimulates proliferation of the host cells, allowing further multiplication of the parasite. The local '''[[Lymph Nodes - Anatomy & Physiology|lymph nodes]]''' are first infected. | ||
| − | Schizonts then '''disseminate''' through the '''[[ | + | Schizonts then '''disseminate''' through the '''[[Category:Primary Lymphoid Tissue | lymphoid tissues]]''' before differentiating into '''merozoites'''. |
The merozoites enter the '''[[Erythrocytes | erythrocytes]]''' and form '''piroplasms''' which are '''infective to ticks''' and capable of sexual reproduction. | The merozoites enter the '''[[Erythrocytes | erythrocytes]]''' and form '''piroplasms''' which are '''infective to ticks''' and capable of sexual reproduction. | ||
| − | Sexual reproduction occurs within the nymph and larval stages of the [[Ticks |tick]] and the final infective stage is present within the '''salivary glands''' and is transmitted to mammalian hosts when bloodfeeding. | + | Sexual reproduction occurs within the nymph and larval stages of the [[Ticks | tick]] and the final infective stage is present within the '''salivary glands''' and is transmitted to mammalian hosts when bloodfeeding. |
Transmission in the tick is then '''[[Ticks#Disease Transmission|trans-stadial]]'''. | Transmission in the tick is then '''[[Ticks#Disease Transmission|trans-stadial]]'''. | ||
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==Diseases== | ==Diseases== | ||
| − | + | [[Image:Lymph node smear East Coast Fever.jpg|thumb|right|200px|Lymph node smear of a cow with East Coast Fever - Drs. Elizabeth Howerth and Bruce LeRoy, Department of Pathology, UGA College of Veterinary Medicine]] | |
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| + | [[Image:H and E stain brain East Coast Fever.jpg|thumb|right|200px|H and E stain of brain and meningeal vessels of a cow with East Coast Fever - Drs. Elizabeth Howerth and Bruce LeRoy, Department of Pathology, UGA College of Veterinary Medicine]] | ||
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| + | [[Theileriosis - Cattle | Bovine Theileriosis]] | ||
[[East Coast Fever]] | [[East Coast Fever]] | ||
| − | + | ==Theileria parva== | |
| + | Also Known As ''T. mutans'' and ''T. sergenti''. | ||
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| + | Primarily a parasite of '''African buffalo'''. | ||
| − | + | Transmitted by a wide range of [[Ticks | tick]] hosts and also the burrowing mite, '''''[[Sarcoptes | Sarcoptes scabei]]'''''. | |
| − | + | The cause of '''[[Theileriosis - Cattle | Bovine Theileriosis]]''' and '''[[East Coast Fever]]''' | |
| − | + | Forms '''rod shaped''' piroplasms within host [[Erythrocytes | erythrocytes]]. | |
| − | + | Shows extreme antigenic diversity across its geographical distribution, although parasites isolated in different diseases are genetically identical. | |
| − | + | Can also infect sheep and mice. | |
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| − | ''T. | + | ==Theileria annulata== |
| + | Also Known As ''T. dispar'' | ||
| − | + | Also a cause of [[Theileriosis - Cattle | Bovine Theileriosis]] | |
| − | + | Infects '''[[Macrophages | macrophages]]''' and '''[[B cells| B Lymphocytes]]'''. | |
| − | '' | ||
| + | Forms '''round or oval''' piroplasma within host [[Erythrocytes | erythrocytes]]. | ||
| − | + | Also infects sheep and yaks | |
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==References== | ==References== | ||
<references/> | <references/> | ||
| − | + | Animal Health & Production Compendium, '''Theileria datasheet''', accessed 04/06/2011 @ http://www.cabi.org/ahpc/ | |
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| + | ==Test yourself with the Piroplasmida Flashcards== | ||
| + | [[Piroplasmida_Flashcards|Piroplasmida Flashcards]] | ||
[[Category:Piroplasmida]] | [[Category:Piroplasmida]] | ||
| − | [[Category: | + | [[Category:To_Do_-_CABI review]] |
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Revision as of 11:46, 4 June 2011
| Theileria spp | |
|---|---|
| Kingdom | Protista |
| Phylum | Protozoa |
| Order | Piroplasmorida |
| Family | Theileriidae |
| Genus | Theileria |
| Species | Theileria parva and others |
Introduction
Theileria species are a group of protozoan pathogens causing severe lymphatic proliferative disease in cattle.
T. parva is the species of most veterinary importance, affecting cattle in Central and Eastern Africa.
Other species cause significant economic losses in the Mediterranean, Middle East and Northern Africa.
Lifecycle
Theileria are transmitted via the Haemaphysalis and Rhipicephalus and Dermacentor species of tick vectors.
Sporozoites enter mononuclear cells of the host and develop into trophozoites and multinucleate schizonts by asexual reproduction. This process stimulates proliferation of the host cells, allowing further multiplication of the parasite. The local lymph nodes are first infected.
Schizonts then disseminate' through the ' before differentiating into merozoites.
The merozoites enter the erythrocytes and form piroplasms which are infective to ticks and capable of sexual reproduction.
Sexual reproduction occurs within the nymph and larval stages of the tick and the final infective stage is present within the salivary glands and is transmitted to mammalian hosts when bloodfeeding.
Transmission in the tick is then trans-stadial.
In endemic areas, endemic stability is often reached, in which most or all cattle may be infected and be carriers and most ticks are also infected, but young calves gain solid immunity from their immune dams and therefore rarely show clinical disease. This state however takes time to stabilise and will cause significant economic losses in the process.
For more information on ticks as vectors, see Tick Disease Transmission.
Pathogenesis
Lymphocytes are killed by invading protozoa and later in disease, lymphopoeisis is reduced and prevented.
Diseases
Theileria parva
Also Known As T. mutans and T. sergenti.
Primarily a parasite of African buffalo.
Transmitted by a wide range of tick hosts and also the burrowing mite, Sarcoptes scabei.
The cause of Bovine Theileriosis and East Coast Fever
Forms rod shaped piroplasms within host erythrocytes.
Shows extreme antigenic diversity across its geographical distribution, although parasites isolated in different diseases are genetically identical.
Can also infect sheep and mice.
Theileria annulata
Also Known As T. dispar
Also a cause of Bovine Theileriosis
Infects macrophages and B Lymphocytes.
Forms round or oval piroplasma within host erythrocytes.
Also infects sheep and yaks
References
Animal Health & Production Compendium, Theileria datasheet, accessed 04/06/2011 @ http://www.cabi.org/ahpc/