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==Primary Liver Tumours==
==Primary Liver Tumours==
===Hepatocytic===
===Hepatocytic===
*more in dogs and cats
*more in dogs and cats
=====Gross=====
=====Gross=====
*can be very variable appearing as sheets or cords of neoplastic cells
*can be very variable appearing as sheets or cords of neoplastic cells
*cells generally smaller with a higher nucleus to cytoplasmic ratio
*cells generally smaller with a higher nucleus to cytoplasmic ratio
===Cholangiocellular - bile duct===
===Cholangiocellular - bile duct===
*ductal and acinar proliferation in abundant fibrous tissue
*ductal and acinar proliferation in abundant fibrous tissue
*sometimes papillary formations
*sometimes papillary formations
==Secondary Liver Tumours==
==Secondary Liver Tumours==
*from a variety of origins
*from a variety of origins
==Pancreatic==
[[Image:Pancreatic carcinoma.jpg|right|thumb|100px|<small><center>Pancreatic carcinoma (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
[http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=11616 Image of haemorrhage and pancreatic carcinoma in a cat from Cornell Veterinary Medicine]
*In older dogs, more common in Airedale terriers, rare in cats, other species too
*Tend to arise centrally in the gland
*Highly invasive and infiltrative
*Metastases to the [[Liver - Anatomy & Physiology|liver]], visceral serosa, abdominal [[Lymph Nodes - Anatomy & Physiology|lymph nodes]], [[Spleen - Anatomy & Physiology|spleen]], [[Adrenal Glands - Anatomy & Physiology|adrenals]] etc.
*Similar to malignant ovarian tumours - implant on the [[Peritoneal Cavity - Anatomy & Physiology|peritoneum]]
===Gross appearance===
[[Image:Pancreatic carcinoma histo.jpg|right|thumb|100px|<small><center>Pancreatic carcinoma (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
*Usually spherical nodules with adhesions to nearby structures
*Single or multiple, variable size
*Greyish or yellow fibrous tissue - firm on cutting
*May show internal necrosis and haemorrhage
*Some tumours may contain cysts wih mucinous content
*Adhesions may occur
===Microscopic appearance===
*May be well differentiated with normal acini and ducts
*Or diffuse sheet of undifferentiated cells
==Endocrine Pancreatic==
*Larger than adenomas
*Multilobular
*Invasive into parenchyma and surrounding tissue
*Metastasis into [[Lymph Nodes - Anatomy & Physiology|lymph nodes]], [[Liver - Anatomy & Physiology|liver]] mesentery, omentum
*Few mitotic figures
==Peritoneal==
*'''Carcinomas'''
**[http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=11314 Image of carcinoma in a cow's peritoneum from Cornell Veterinary Medicine]
**Must be differentiated from mesotheliomas
**More common than sarcomas
**Sometimes very scirrhous
**May resemble chronic [[Peritonitis|peritonitis]] when present with ascites
**Absence of adhesions
{{Learning
|Vetstream = [https://www.vetstream.com/canis/search?s=carcinoma carcinoma]
}}
[[Category:Liver,_Primary_Tumours]]
[[Category:Liver,_Primary_Tumours]]
[[Category:Liver,_Secondary_Tumours]]
[[Category:Liver,_Secondary_Tumours]]
[[Category:Pancreas_-_Hyperplastic_and_Neoplastic_Pathology]]
[[Category:Endocrine_System_-_Pathology]]
[[Category:Peritoneal_Cavity_-_Neoplastic_Pathology]]
[[Category:Neoplasia]]