Difference between revisions of "Consequences of Gastric Disease - Pathology"

Revision as of 23:28, 25 August 2008

Fluid loss is evident as:
1. An increased PCV or haematocrit.
2. An increased total protein concentration.
3. A prerenal azotaemia.

The main losses are of H⁺ and Cl^-, and also K⁺
Can potentially cause metabolic alkalosis, although this is only likely with disease which stops at the pylorus, e.g.: pyloric outflow obstruction.
- In cases where mild alkalosis occurs, homeostatic mechanisms produce a more alkaline urine to restore normal body pH.
- However, in severe metablolic alkalosis with marked dehydration, acidic urine may be produced- this is termed paradoxical aciduria.
  - Because vomiting induceses hypokalaemia, there is an overriding stimulus in the kidney for Na⁺ (and therefore water) retention.
  - Na+ can only be resorbed in exchange for H+
    - H⁺ is therefore excreted in the urine, causing it to be acidic.
  - Vomiting also induces hypochloraemia, meaning bicarbonate rather than chloride is resorbed with the Na+ to maintain electrical neutrality
    - This perpetuates the alkalosis.
Vomiting does not occur in the ruminant although abomasal content may reflux into the forestomachs.
- Sequestration of secretions in the abomasum will have similar effects to pyloric outflow obstruction with vomiting in the monogastric animal.
  - e.g. abomasal torsion
  - Causes dehydration, hypochloraemia, hypokalaemia and metabolic alkalosis.

Lesions in the small intestine can also lead to vomiting
- Both gastric acid and pancreatic and intestinal bicarbonate secretions are lost
  - Animal consequently has a normal pH or may even be acidotic.

Associated with some forms of gastritis.
- e.g. Ostertagiasis
Causes failure of digestion.
- Anorexia and weight loss follow.
Increases the number of bacteria in the stomach.
Diarrhoea reults
- Cause is unknwn is unknown but appears to be related to the elevated pH.

@@ Line 33: / Line 33: @@
 *** [[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|Vomiting]] also induces hypochloraemia, meaning bicarbonate rather than chloride is resorbed with the Na+ to maintain electrical neutrality
 **** This perpetuates the alkalosis.
-* [[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|Vomiting]] does not occur in the ruminant although [[The Abomasum|abomasal]] content may reflux into the [[Stomach and Abomasum - Anatomy & Physiology|forestomachs]].
+* [[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|Vomiting]] does not occur in the ruminant although [[The Abomasum - Anatomy & Physiology|abomasal]] content may reflux into the [[Stomach and Abomasum - Anatomy & Physiology|forestomachs]].
-** Sequestration of secretions in the [[The Abomasum|abomasum]] will have similar effects to pyloric outflow obstruction with [[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|vomiting]] in the monogastric animal.
+** Sequestration of secretions in the [[The Abomasum - Anatomy & Physiology|abomasum]] will have similar effects to pyloric outflow obstruction with [[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|vomiting]] in the monogastric animal.
 *** e.g. abomasal torsion
 *** Causes dehydration, hypochloraemia, hypokalaemia and metabolic alkalosis.