Difference between revisions of "Morantel"
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m (Levamisole and Morantel moved to Morantel: They belong to different drug classes.) |
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| − | + | These belong to the tetrahydropyrimidines class of drugs and a known by farmers as yellow drenches. The product code in the UK is '''2-LM'''. | |
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| + | ==Levamisole== | ||
| + | * This is one of the most widely used anthelmintics and can be given orally, by injection or as a pour on. | ||
| + | * It is active against adult '''[[Nematodes]]''', but has limited action against the larval stages, especially the hypobiotic phase. | ||
| + | * It is a cholinergic agonist at neural and nuromuscular junctions causing a '''spastic paralysis''' of the nematode. The nematodes succumb rapidly to it. | ||
| + | * It is rapidly absorbed and excreted and it's potency is related to it's peak plasma concentration. Therefore pour-on products need a higher dose, as they are absorbed more slowly, to reach the same plasma concentrations. | ||
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| + | ==Morantel== | ||
* This works in a similar fashion to levamisole but isn't absorbed by the alimentary tract. | * This works in a similar fashion to levamisole but isn't absorbed by the alimentary tract. | ||
* It has limited activity against larval forms and so has little uses. | * It has limited activity against larval forms and so has little uses. | ||
* Morantel is used in some rumenal boluses. | * Morantel is used in some rumenal boluses. | ||
| − | * Pyrantel, a similar product, is used against equine [[cestodes]]. | + | * Pyrantel, a similar product, is used for against equine [[cestodes]]. |
Revision as of 11:42, 3 November 2008
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These belong to the tetrahydropyrimidines class of drugs and a known by farmers as yellow drenches. The product code in the UK is 2-LM.
Levamisole
- This is one of the most widely used anthelmintics and can be given orally, by injection or as a pour on.
- It is active against adult Nematodes, but has limited action against the larval stages, especially the hypobiotic phase.
- It is a cholinergic agonist at neural and nuromuscular junctions causing a spastic paralysis of the nematode. The nematodes succumb rapidly to it.
- It is rapidly absorbed and excreted and it's potency is related to it's peak plasma concentration. Therefore pour-on products need a higher dose, as they are absorbed more slowly, to reach the same plasma concentrations.
Morantel
- This works in a similar fashion to levamisole but isn't absorbed by the alimentary tract.
- It has limited activity against larval forms and so has little uses.
- Morantel is used in some rumenal boluses.
- Pyrantel, a similar product, is used for against equine cestodes.