Difference between revisions of "Morantel"
Jump to navigation
Jump to search
m (Levamisole and Morantel moved to Morantel: They belong to different drug classes.) |
m (→Levamisole) |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 8: | Line 8: | ||
}} | }} | ||
| − | + | These belong to the tetrahydropyrimidines class of drugs and a known by farmers as yellow drenches. The product code in the UK is '''2-LM'''. | |
| + | |||
| + | ==Levamisole== | ||
| + | * This is one of the most widely used anthelmintics and can be given orally, by injection or as a pour on. | ||
| + | * It is active against adult '''[[Nematodes]]''', but has limited action against the larval stages, especially the hypobiotic phase. | ||
| + | * It is a cholinergic agonist at neural and neuromuscular junctions causing a '''spastic paralysis''' of the nematode. The nematodes succumb rapidly to it. | ||
| + | * It is rapidly absorbed and excreted and its potency is related to its peak plasma concentrations. Therefore pour-on products need a higher dose, as they are absorbed more slowly, to reach the same plasma concentrations. | ||
| + | |||
| + | ==Morantel== | ||
* This works in a similar fashion to levamisole but isn't absorbed by the alimentary tract. | * This works in a similar fashion to levamisole but isn't absorbed by the alimentary tract. | ||
* It has limited activity against larval forms and so has little uses. | * It has limited activity against larval forms and so has little uses. | ||
* Morantel is used in some rumenal boluses. | * Morantel is used in some rumenal boluses. | ||
| − | * Pyrantel, a similar product, is used against equine [[cestodes]]. | + | * Pyrantel, a similar product, is used for against equine [[cestodes]]. |
Revision as of 21:14, 29 September 2009
 |
This article has been peer reviewed but is awaiting expert review. If you would like to help with this, please see more information about expert reviewing. |
|
These belong to the tetrahydropyrimidines class of drugs and a known by farmers as yellow drenches. The product code in the UK is 2-LM.
Levamisole
- This is one of the most widely used anthelmintics and can be given orally, by injection or as a pour on.
- It is active against adult Nematodes, but has limited action against the larval stages, especially the hypobiotic phase.
- It is a cholinergic agonist at neural and neuromuscular junctions causing a spastic paralysis of the nematode. The nematodes succumb rapidly to it.
- It is rapidly absorbed and excreted and its potency is related to its peak plasma concentrations. Therefore pour-on products need a higher dose, as they are absorbed more slowly, to reach the same plasma concentrations.
Morantel
- This works in a similar fashion to levamisole but isn't absorbed by the alimentary tract.
- It has limited activity against larval forms and so has little uses.
- Morantel is used in some rumenal boluses.
- Pyrantel, a similar product, is used for against equine cestodes.