Difference between revisions of "Short Bowel Syndrome"

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==Description==
 
==Description==
'''Short bowel syndrome''' occurs when greater than 75-90% of the [[Small Intestine Overview - Anatomy & Physiology|small intestine]] is absent.  It is most commonly caused by iatrogenic surgical resection, although congenital anomaly can occur in rare cases.  The remaining [[Small Intestine Overview - Anatomy & Physiology|small intestine]] cannot adequately absorb nutrients and electrolytes, resulting in [[Diarrhoea|diarrhoea]].  If the [[Colon - Anatomy & Physiology|ileocolic valve]] has been removed, large numbers of bacteria are more likely to reach the small intestine.  Changes in gastrointestinal hormone regulation such as hypergastrinaemia and increased acid secretion may occur.
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'''Short bowel syndrome''' occurs when greater than 75-90% of [[Small Intestine - Anatomy & Physiology|small intestine]] is absent.  It is most commonly caused by iatrogenic surgical resection, although congenital anomaly can occur in rare cases.  The remaining [[Small Intestine - Anatomy & Physiology|small intestine]] cannot adequately absorb nutrients and electrolytes, resulting in [[Diarrhoea|diarrhoea]].  If the [[Colon - Anatomy & Physiology|ileocolic valve]] has been removed, large number of bacteria is more likely to reach the small intestine.  Changes in gastrointestinal hormone regulation such as hypergastrinaemia and increased acid secretion may occur.
  
This syndrome may only be transient until the remaining intestine can undergo adaptive [[Cell Growth Disorders#Hyperplasia|hyperplasia]].  However, it does not necessary occur in all cases of massive intestinal resection.  Large resection of intestine should ideally be avoided in the first instance.  If needed, it may be better to perform a second surgery 24-48 hours after the first surgery.
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This syndrome may only be transient until the remaining intestine can undergo adaptive [[Disorders of Cell Growth - Pathology#Hyperplasia|hyperplasia]].  However, it does not necessary occur in all cases of massive intestinal resection.  Large resection of intestine should ideally be avoided in the first instance.  If needed, it may be better to perform a second surgery 24-48 hours after the first surgery.
  
 
==Diagnosis==
 
==Diagnosis==
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===Nutritional support===
 
===Nutritional support===
 
*Total or partial parenteral nutrition may be required to provide adequate nutrition until adaptive hyperplasia takes place.
 
*Total or partial parenteral nutrition may be required to provide adequate nutrition until adaptive hyperplasia takes place.
*At the same time, it is important to continue oral feeding to stimulate mucosal [[Cell Growth Disorders#Hypertrophy|hypertrophy]].
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*At the same time, it is important to continue oral feeding to stimulate mucosal [[Disorders of Cell Growth - Pathology#Hypertrophy|hypertrophy]].
  
 
===Dietary modification===
 
===Dietary modification===
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===Antimicrobials===
 
===Antimicrobials===
*A secondary [[Antibiotic Responsive Diarrhoea|antibiotic responsive diarrhoea]] may result if the ileocaecal valve is removed.
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*A secondary [[Small Intestinal Bacterial Overgrowth and Antibiotic Responsive Diarrhoea - WikiClinical|antibiotic responsive diarrhoea]] may result if the ileocaecal valve is removed.
 
*[[Nitroimidazoles|Metronidazole]] or [[Macrolides and Lincosamides|tylosin]] can be given in these cases.
 
*[[Nitroimidazoles|Metronidazole]] or [[Macrolides and Lincosamides|tylosin]] can be given in these cases.
  
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*Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) '''BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition)''' ''BSAVA''
 
*Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) '''BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition)''' ''BSAVA''
 
*Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier''.
 
*Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier''.
 
 
 
[[Category:Intestine_-_Physical_Disturbances]][[Category:To_Do_-_Clinical]]
 
[[Category:Intestine_-_Physical_Disturbances]][[Category:To_Do_-_Clinical]]
[[Category:Intestinal Diseases - Dog]][[Category:Intestinal Diseases - Cat]]
 

Revision as of 12:28, 28 June 2010


Category:WikiClinical CanineCow
Category:WikiClinical FelineCow


Description

Short bowel syndrome occurs when greater than 75-90% of small intestine is absent. It is most commonly caused by iatrogenic surgical resection, although congenital anomaly can occur in rare cases. The remaining small intestine cannot adequately absorb nutrients and electrolytes, resulting in diarrhoea. If the ileocolic valve has been removed, large number of bacteria is more likely to reach the small intestine. Changes in gastrointestinal hormone regulation such as hypergastrinaemia and increased acid secretion may occur.

This syndrome may only be transient until the remaining intestine can undergo adaptive hyperplasia. However, it does not necessary occur in all cases of massive intestinal resection. Large resection of intestine should ideally be avoided in the first instance. If needed, it may be better to perform a second surgery 24-48 hours after the first surgery.

Diagnosis

Clinical Signs

  • Small intestinal diarrhoea, often with undigested food particles in the faeces
  • Severe weight loss

In cases which occur after surgical bowel resection, the presenting clinical signs are sufficient to make a diagnosis. In cases of congenital origin, a plain or contrast radiography is required.


Treatment

Nutritional support

  • Total or partial parenteral nutrition may be required to provide adequate nutrition until adaptive hyperplasia takes place.
  • At the same time, it is important to continue oral feeding to stimulate mucosal hypertrophy.

Dietary modification

  • Small, frequent meals of highly digestible, low fat diet is recommended.
  • Vitamin supplementation may be required.

Antimicrobials

Antisecretory agents & antacids

  • These may be needed in cases which are poorly responsive diet and antimicrobials alone. Its aim is to lessen diarrhoea and gastric hypersecretion.
  • Antisecretory agents such as loperamide, diphenoxylate.
  • Antacids such as ranitidine, famotidine.


Prognosis

This is dependent on the length of the small intestine left and response to therapy. If adequate adaption occurs, the patient may respond well and eventually be able to consume a near-normal diet. However, there will always be a limitation in the absorptive capacity of these animals. Some cases may respond poorly and can never be fed on a normal diet and others may die. Malnourished animals have a poorer prognosis.


References

  • Ettinger, S.J. and Feldman, E. C. (2000) Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2 (Fifth Edition) W.B. Saunders Company.
  • Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition) BSAVA
  • Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier.