Difference between revisions of "Glanders"

Revision as of 16:37, 27 July 2010

Caused by Burkholderia (Pseudomonas) mallei
Exists in eastern Europe and Asia
Notifiable in UK
Characterised by multiple small submucosal nasal nodules which liquefy and ulcerate
- Cores of neutrophils surrounded by a rim of macrophages and granulation tissue
In addition may have similar nodules in lungs, lymph nodes and cutaneous lymphatics
Clinical signs: fever and head/ neck lymphadenitis, rhinitis

Largely eradicated but sporadic cases in Middle East, India, China
Pathogenesis:
- Transmited by ingestion of food/water contaminated by nasal discharge of infected Equidae; occasionally via inhalation or skin wounds
- Organism invades nasopharyngeal mucosa and spreads to other tissues via lymphatics
- Presence of B. mallei in host causes hypersensitivity reaction
Clinical infections:
- Acute septicaemic form with fever, mucopurulent nasal discharge and respiratory signs; death within weeks
- Chronic disease more common:
  - Nasal form: rhinitis; ulcerative nodules develop on mucosa of nasal septum and lower part of turbinates; purulent blood-stained nasal discharge; regional lymphadenitis
  - Respiratory form: respiratory distress; granulomatous lesions throughout lungs
  - Cutaneous form (farcy): lymphangitis; nodules along lymphatic vesselsof limbs; ulcers develop and discharge pus
  - May die after several months or recover and shed organisms from respiratory tract or skin
- Carnivores may contract disease by eating infected carcasses
Diagnosis:
- Specimens include discharges from lesions and blood for serology
- Grows on media containing 1% glycerol; most strains are non-lactose fermenters on MacConkey agar
- Complement fixation and agglutination
- Serology
- Mallein test: mallein injected intradermally below lower eyelid; local swelling and discharge indicates positive reation
Treatment/control:
- Test and slaughter policy where disease exotic
- Disinfection of contaminated areas using formalin or an iodophor

@@ Line 1: / Line 1: @@
-{{OpenPagesTop}}
+*Caused by [[Burkholderia mallei|''Burkholderia (Pseudomonas) mallei'']]
-{{Taxobox
+*Exists in eastern Europe and Asia
-|name               =''Burkholderia mallei''
+*Notifiable in UK
-|phylum             =Proteobacteria
+*Characterised by multiple small submucosal [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|nasal nodules]] which liquefy and ulcerate
-|class              =Beta Proteobacteria
+**Cores of [[Neutrophils|neutrophils]] surrounded by a rim of macrophages and [[Chronic Inflammation - Pathology#Granulation tissue|granulation tissue]]
-|order              =Burkholderiales
+*In addition may have similar nodules in [[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|lungs]], '''lymph nodes''' and '''cutaneous lymphatics'''
-|family             =Burkholderiaceae
+*Clinical signs: fever and head/ neck lymphadenitis, [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|rhinitis]]
-|genus              =Burkholderia
-|species            =''B.mallei''
-}}
-Also known as: '''''Farcy'''''
+*Largely eradicated but sporadic cases in Middle East, India, China
-Caused by '''''Burkholderia mallei''''' Also known as: ''Pseudomonas mallei — B.mallei''
+*Pathogenesis:
+**Transmited by ingestion of food/water contaminated by nasal discharge of infected ''Equidae''; occasionally via inhalation or skin wounds
+**Organism invades nasopharyngeal mucosa and spreads to other tissues via lymphatics
+**Presence of ''B. mallei'' in host causes hypersensitivity reaction
+*Clinical infections:
+**Acute septicaemic form with fever, mucopurulent nasal discharge and respiratory signs; death within weeks
+**Chronic disease more common:
+***Nasal form: [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|rhinitis]]; ulcerative nodules develop on mucosa of nasal septum and lower part of turbinates; purulent blood-stained nasal discharge; regional lymphadenitis
+***Respiratory form: respiratory distress; granulomatous lesions throughout lungs
+***Cutaneous form (farcy): lymphangitis; nodules along lymphatic vesselsof limbs; ulcers develop and discharge pus
+***May die after several months or recover and shed organisms from respiratory tract or skin
+**Carnivores may contract disease by eating infected carcasses
+*Diagnosis:
+**Specimens include discharges from lesions and blood for serology
+**Grows on media containing 1% glycerol; most strains are non-lactose fermenters on MacConkey agar
+**Complement fixation and agglutination
+**Serology
+**Mallein test: mallein injected intradermally below lower eyelid; local swelling and discharge indicates positive reation
+*Treatment/control:
+**Test and slaughter policy where disease exotic
+**Disinfection of contaminated areas using formalin or an iodophor
-==Introduction==
+[[Category:Horse]]
-'''Glanders''' is a contagious disease caused by '''''Burkholderia (Pseudomonas) mallei'''''. It exists in '''acute''' and '''chronic''' forms. Animals are infected by ingestion of contaminated feed or water, inhalation or via open wounds. The organism invades mucosa and disseminates to other tissue via the lymphatics resulting in nodules and ulcers in the respiratory tract and on the skin.
-''Burkholderia mallei'' is a species of the ''[[Burkholderia species - Overview|Burkholderia]]'' genus. The presence of ''B. mallei'' in the host causes hypersensitivity reactions.
-Three forms of the condition have been described; animals will show signs of one or more forms.
-'''Pulmonary form''':
-Small calcified or caseous nodules develop in the lungs, the surrounding tissue becomes inflamed and consolidated. The resulting pneumonia causes respiratory distress and coughing. The nodules frequently degenerate and release their contents into the bronchioles which results in spread of the infection into the upper airways.
-'''Nasal form''':
-Nodules form on the nasal mucosa, nasal septum and nasal turbinates. These break down to become ulcerative with raised irregular borders, the lesions may heal to form characteristic star shaped scars. A thick mucopurulent discharge is seen at the nostrils. The local lymph nodes are enlarged and as the disease progresses, they become firm and adhere to underlyinig tissues.
-'''Cutaneous form (Farcy)''':
-Nodules form overlying lymph vessels, especially of the extremities and limbs. These nodules rupture to release thick pus which is highly infectious.
-Carnivores can also be infected by ingestion of infected carcasses.
-The disease is '''zoonotic''', humans are infected by inoculation through a wound and mortality is high.
-==Signalment==
-Equidae are most commonly affected, horses tend to get the chronic form and mules and donkeys the acute form.
-The disease was once widespread in the UK but was eradicated in 1928 and is now a Notifiable disease. Animals imported from areas at high risk of the disease must be blood tested before entry into the UK is permitted. Distribution is limited to parts of SE Asia, The Middle East, India, North Africa, China and Mongolia.
-==Diagnosis==
-A diagnosis of ''B.mallei'' can be made by collecting specimens, including discharges from lesions and blood for serology. The bacteria grows on media containing 1% glycerol. Most strains are non-lactose fermenters on MacConkey agar. Complement fixation and agglutination can be carried out, as can serology.
-===Clinical Signs===
-Clinical signs may be sufficient to diagnose the condition, however they do not develop until the disease is advanced, therefore specific tests are indicated in suspected cases to aid prompt diagnosis.
-====Acute====
-* Pyrexia
-* Mucopurulent nasal discharge
-* Ulceration of nasal mucosa
-* Coughing
-* Death
-Affected animals are septicaemic and die within a few days.
-====Chronic====
-* Nodular, ulcerative nasal lesions
-* Subcutaneous nodules which rupture and discharge exudate
-* Enlarged lymph nodes
-Animals are debilitated and show clinical signs for several months, the disease may be fatal or the animal may appear to recover but it will act as a carrier and source of infection for spread of the disease.
-===Clinical Tests===
-The '''Mallein test''' is used most frequently to diagnose the condition, a fraction of the causative organism is injected intradermally into the eyelid or applied as eyedrops, a positive result is seen as local swelling and discharge 1-2 days post testing.
-===Laboratory Tests===
-Other diagnostic tests include an [[ELISA testing|Elisa]], complement fixation and culture of the organism from exudative lesions.
-==Treatment==
-There is no vaccine available. Prevention and control focuses on prompt detection and slaughter of infected animals and complete quarantine and disinfection of the affected premises.
-==Prognosis==
-Prognosis is poor, the disease is usually fatal. Animals which survive should be slaughtered to prevent spread of the disease.
-<big>Also see: [[Glanders (Farcy) - Donkey|'''Glanders in Donkeys''']]</big>
-{{Learning
-|literature search = [http://www.cabdirect.org/search.html?q=%28%28title%3A%28%22Pseudomonas+mallei%22%29%29%29+OR+%28%28title%3A%28%22Burkholderia+mallei%22%29%29%29 ''Burkholderia mallei'' publications]
-[http://www.cabdirect.org/search.html?it=any&q1=glanders&calendarInput=yyyy-mm-dd&occuring1=title&show=all&rowId=1&rowId=2&rowId=3&options1=AND&options2=AND&options3=AND&occuring3=freetext&occuring2=freetext&publishedend=yyyy&la=any&publishedstart=yyyy&fq=sc%3A%22ve%22&y=7&x=37 Glanders publications]
-}}
-==References==
-* http://www.defra.gov.uk/foodfarm/farmanimal/diseases/atoz/glanders/
-* Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial''
-{{review}}
-{{OpenPages}}
-[[Category:Expert_Review]]
 [[Category:Respiratory_Bacterial_Infections]]
-[[Category:Zoonoses]]
+[[Category:To_Do_-_lizzyk]]
-[[Category:Respiratory Diseases - Horse]]

Difference between revisions of "Glanders"

Revision as of 16:37, 27 July 2010

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