Difference between revisions of "Glanders"
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| − | + | ==Description== | |
| − | + | '''Glanders''' is a contagious disease caused by [[Burkholderia mallei|''Burkholderia (Pseudomonas) mallei'']]. It exists in acute and chronic forms. | |
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| − | + | Three forms of the condition have been described; animlas will show signs of one of more forms. | |
| − | + | *Pulmonary form: | |
| − | + | *Nasal form: | |
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| − | + | * Cutaneous form: | |
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==Signalment== | ==Signalment== | ||
Equidae are most commonly affected, horses tend to get the chronic form and mules and donkeys the acute form. | Equidae are most commonly affected, horses tend to get the chronic form and mules and donkeys the acute form. | ||
| − | The disease was once widespread in the UK but was eradicated in 1928 and is now a Notifiable disease | + | The disease was once widespread in the UK but was eradicated in 1928 and is now a Notifiable disease. Distribution is limited to parts of SE Asia, The Middle East, India, North Africa, China and Mongolia. |
==Diagnosis== | ==Diagnosis== | ||
| − | + | Clinical signs may be sufficient to diagnose the condition, however they do not develop until the diease is advanced therefore specific tests are indicated in suspected cases to aid prompt diagnosis. | |
===Clinical Signs=== | ===Clinical Signs=== | ||
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====Acute==== | ====Acute==== | ||
* Pyrexia | * Pyrexia | ||
| − | * Mucopurulent nasal | + | * Mucopurulent nasal discharage |
* Ulceration of nasal mucosa | * Ulceration of nasal mucosa | ||
* Coughing | * Coughing | ||
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====Chronic==== | ====Chronic==== | ||
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* Nodular, ulcerative nasal lesions | * Nodular, ulcerative nasal lesions | ||
| − | * Subcutaneous nodules which | + | * Subcutaneous nodules which rupure and discharge exudate |
* Enlarged lymph nodes | * Enlarged lymph nodes | ||
| − | + | ===Clinical tests=== | |
| + | The Mallein test is used most frquently to diagnose the condition, a fraction of the causative organism is injected intradermally into the eyelid or applied as eyedrops, a positive result is seen as local swelling and discharge 1-2 days post testing. | ||
| − | === | + | ===Laboratory Tests=== |
| − | + | Other diagnostic tests include an Elisa, complement fixation and culture of the orgamism from exudative lesions. | |
| − | === | + | ===Pathology=== |
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==Treatment== | ==Treatment== | ||
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==Prognosis== | ==Prognosis== | ||
| − | + | prognosis is poor, the diease is usually fatal. Animalss which survive should be slaughtered to prevent spread of the disease. | |
| − | + | ==References== | |
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| + | *Characterised by multiple small submucosal [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|nasal nodules]] which liquefy and ulcerate | ||
| + | **Cores of [[Neutrophils|neutrophils]] surrounded by a rim of macrophages and [[Chronic Inflammation - Pathology#Granulation tissue|granulation tissue]] | ||
| + | *In addition may have similar nodules in [[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|lungs]], '''lymph nodes''' and '''cutaneous lymphatics''' | ||
| + | *Clinical signs: fever and head/ neck lymphadenitis, [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|rhinitis]] | ||
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| − | + | *Pathogenesis: | |
| − | + | **Transmited by ingestion of food/water contaminated by nasal discharge of infected ''Equidae''; occasionally via inhalation or skin wounds | |
| − | + | **Organism invades nasopharyngeal mucosa and spreads to other tissues via lymphatics | |
| − | + | **Presence of ''B. mallei'' in host causes hypersensitivity reaction | |
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| + | **Chronic disease more common: | ||
| + | ***Nasal form: [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|rhinitis]]; ulcerative nodules develop on mucosa of nasal septum and lower part of turbinates; purulent blood-stained nasal discharge; regional lymphadenitis | ||
| + | ***Respiratory form: respiratory distress; granulomatous lesions throughout lungs | ||
| + | ***Cutaneous form (farcy): lymphangitis; nodules along lymphatic vesselsof limbs; ulcers develop and discharge pus | ||
| + | ***May die after several months or recover and shed organisms from respiratory tract or skin | ||
| + | **Carnivores may contract disease by eating infected carcasses | ||
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[[Category:Respiratory_Bacterial_Infections]] | [[Category:Respiratory_Bacterial_Infections]] | ||
| − | [[Category: | + | [[Category:To_Do_-_lizzyk]] |
| − | [[Category: | + | [[Category:Respiratory_Disorders_-_Horse]] |
Revision as of 14:17, 31 July 2010
Description
Glanders is a contagious disease caused by Burkholderia (Pseudomonas) mallei. It exists in acute and chronic forms.
Three forms of the condition have been described; animlas will show signs of one of more forms.
- Pulmonary form:
- Nasal form:
- Cutaneous form:
Signalment
Equidae are most commonly affected, horses tend to get the chronic form and mules and donkeys the acute form. The disease was once widespread in the UK but was eradicated in 1928 and is now a Notifiable disease. Distribution is limited to parts of SE Asia, The Middle East, India, North Africa, China and Mongolia.
Diagnosis
Clinical signs may be sufficient to diagnose the condition, however they do not develop until the diease is advanced therefore specific tests are indicated in suspected cases to aid prompt diagnosis.
Clinical Signs
Acute
- Pyrexia
- Mucopurulent nasal discharage
- Ulceration of nasal mucosa
- Coughing
- Death
Affected animals are septicaemic and die within a few days.
Chronic
- Nodular, ulcerative nasal lesions
- Subcutaneous nodules which rupure and discharge exudate
- Enlarged lymph nodes
Clinical tests
The Mallein test is used most frquently to diagnose the condition, a fraction of the causative organism is injected intradermally into the eyelid or applied as eyedrops, a positive result is seen as local swelling and discharge 1-2 days post testing.
Laboratory Tests
Other diagnostic tests include an Elisa, complement fixation and culture of the orgamism from exudative lesions.
Pathology
Treatment
There is no vaccine available. Prevention and control focuses on prompt detection and slaughter of infected animals and complete quarantine and disinfection of the affected premises.
Prognosis
prognosis is poor, the diease is usually fatal. Animalss which survive should be slaughtered to prevent spread of the disease.
References
- Characterised by multiple small submucosal nasal nodules which liquefy and ulcerate
- Cores of neutrophils surrounded by a rim of macrophages and granulation tissue
- In addition may have similar nodules in lungs, lymph nodes and cutaneous lymphatics
- Clinical signs: fever and head/ neck lymphadenitis, rhinitis
- Pathogenesis:
- Transmited by ingestion of food/water contaminated by nasal discharge of infected Equidae; occasionally via inhalation or skin wounds
- Organism invades nasopharyngeal mucosa and spreads to other tissues via lymphatics
- Presence of B. mallei in host causes hypersensitivity reaction
- Chronic disease more common:
- Nasal form: rhinitis; ulcerative nodules develop on mucosa of nasal septum and lower part of turbinates; purulent blood-stained nasal discharge; regional lymphadenitis
- Respiratory form: respiratory distress; granulomatous lesions throughout lungs
- Cutaneous form (farcy): lymphangitis; nodules along lymphatic vesselsof limbs; ulcers develop and discharge pus
- May die after several months or recover and shed organisms from respiratory tract or skin
- Carnivores may contract disease by eating infected carcasses
- Chronic disease more common: