Difference between revisions of "Feline Infectious Peritonitis"
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| + | | Also known as: | ||
| + | | '''FIP''' | ||
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| + | ==Description== | ||
A progressive disease of the cat caused by feline [[Coronaviridae|coronavirus]]. FIP arises from a mutation of '''Feline Enteric Coronavirus (FECoV)''' in 5-10% of chronically infected cats and not directly from cat to cat. Two forms of the disease exist the '''wet''' or '''exudative form''' and the '''dry''' or '''non exudative form'''. | A progressive disease of the cat caused by feline [[Coronaviridae|coronavirus]]. FIP arises from a mutation of '''Feline Enteric Coronavirus (FECoV)''' in 5-10% of chronically infected cats and not directly from cat to cat. Two forms of the disease exist the '''wet''' or '''exudative form''' and the '''dry''' or '''non exudative form'''. | ||
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==History and Clinical signs== | ==History and Clinical signs== | ||
| − | FECoV may cause mild respiratory | + | FECoV may cause mild respiratory symptoms and diarrhoea but is often asymptomatic. |
Signs of FIP include, chronic weight loss, anorexia, pyrexia, depression, fever and [[Vasculitis|vasculitis]]. | Signs of FIP include, chronic weight loss, anorexia, pyrexia, depression, fever and [[Vasculitis|vasculitis]]. | ||
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Granulomatous change in the organs are symptomatic of dry FIP. | Granulomatous change in the organs are symptomatic of dry FIP. | ||
FIP has also been documented to cause: | FIP has also been documented to cause: | ||
| − | Uveitis, [[Congenital and Neonatal Disease - Pathology #Hydrocephalus| hydrocephalus]], neurological symptoms, such as ataxia or [[Seizures|seizures]] and chronic [[Diarrhoea|diarrhoea]]. | + | Uveitis, [[Congenital and Neonatal Disease - Pathology #Hydrocephalus| hydrocephalus]], neurological symptoms, such as ataxia or [[CNS Seizures - Pathology|seizures]] and chronic [[Diarrhoea|diarrhoea]]. |
==Diagnosis== | ==Diagnosis== | ||
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Weeks, months or years may intervene between localized primary FECoV infection and FIP development. FECoV replicates in the gut, but FIP spreads systemically in the circulation. FIP then gains the ability to replicate in [[Monocytes|monocytes]] and macrophages. | Weeks, months or years may intervene between localized primary FECoV infection and FIP development. FECoV replicates in the gut, but FIP spreads systemically in the circulation. FIP then gains the ability to replicate in [[Monocytes|monocytes]] and macrophages. | ||
| − | Failure of the [[ | + | Failure of the [[Adaptive Immune System - WikiBlood|immune system]] to clear antibody-antigen complexes leads to immune-mediated disease and deposited complexes cause [[Inflammation - Pathology|inflammation]] and exudation. This leads to characteristic [[Oedema - Pathology| oedema]] as fibrin-rich serum escapes to intercellular spaces. |
Pyogranulomas reactions can develop in major organs as a result of the immune response and the body's failure to clear away excess [[Neutrophils|neutrophils]]. | Pyogranulomas reactions can develop in major organs as a result of the immune response and the body's failure to clear away excess [[Neutrophils|neutrophils]]. | ||
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Cats previously exposed to coronavirus (and therefore with circulating antibody) may be at greater risk as they are more susceptible to taking up virus into mononuclear cells. | Cats previously exposed to coronavirus (and therefore with circulating antibody) may be at greater risk as they are more susceptible to taking up virus into mononuclear cells. | ||
| − | Cats making a biased [[Adaptive Immune System - | + | Cats making a biased [[Adaptive Immune System - WikiBlood #Cellular response: Proliferation and Differentiation|Th-1]] response are more likely to evade infection, whereas cats making a balanced response are at moderate risk and cats making a biased [[Adaptive Immune System - WikiBlood #Cellular response: Proliferation and Differentiation| Th-2]] response are at greater risk, as the virus is best tackled by cell mediation and not antibody. |
==Pathology== | ==Pathology== | ||
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'''Wet form''' | '''Wet form''' | ||
| − | Widespread miliary, white, pinhead granulomas and fibrin deposition, particularly in the serosa of the [[Small Intestine | + | Widespread miliary, white, pinhead granulomas and fibrin deposition, particularly in the serosa of the [[Small Intestine - Anatomy & Physiology|small]] and [[Large Intestine - Anatomy & Physiology |large intestine]] |
| − | High-protein exudates can be found in [[Peritoneal | + | High-protein exudates can be found in [[Peritoneal cavity - Anatomy & Physiology|peritoneal cavity]]. |
'''Dry form''' | '''Dry form''' | ||
| − | Larger, grey granulomatous masses | + | Larger, grey granulomatous masses causing thickening of the wall of the [[Small Intestine - Anatomy & Physiology|small]] and [[Large Intestine - Anatomy & Physiology|large intestine]]. |
====Histological==== | ====Histological==== | ||
| − | Multifocal pyogranulomas on serosa and throughout gut wall. Infiltration by mononuclear cells, [[Lymphocytes | + | Multifocal pyogranulomas on serosa and throughout gut wall. Infiltration by mononuclear cells, [[Lymphocytes|lymphocytes]], plasma cells, [[Macrophages| macrophages]] and a few[[Neutrophils|neutrophils]]. [[Necrosis - Pathology|Necrosis]] and vasculitis will also be seen. |
==Treatment== | ==Treatment== | ||
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==Control== | ==Control== | ||
| − | Conventional [[Vaccines| vaccination]] is counterproductive as antibody worsens infection however a non-systemic vaccine (Primucell) is available outside the UK. Replication confined to nasal mucosa, providing local immunity and cell-mediated immunity and it cannot protect cats already infected with FECoV. | + | Conventional [[Vaccines - WikiBlood| vaccination]] is counterproductive as antibody worsens infection however a non-systemic vaccine (Primucell) is available outside the UK. Replication confined to nasal mucosa, providing local immunity and cell-mediated immunity and it cannot protect cats already infected with FECoV. |
Antibody tests are available to certify FECoV-free cat houses. | Antibody tests are available to certify FECoV-free cat houses. | ||
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==Prognosis== | ==Prognosis== | ||
Very poor. | Very poor. | ||
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==References== | ==References== | ||
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| − | + | [[Category:Coronaviridae]][[Category:Cat]] | |
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| − | [[Category:Coronaviridae]][[Category:Cat | ||
[[Category:Enteritis, Granulomatous]] | [[Category:Enteritis, Granulomatous]] | ||
[[Category:Enteritis,_Viral]] | [[Category:Enteritis,_Viral]] | ||
[[Category:Hepatitis,_Viral]] | [[Category:Hepatitis,_Viral]] | ||
| − | [[Category: | + | [[Category:To_Do_-_Caz]] |
| − | [[Category:Expert_Review | + | [[Category:Expert_Review]] |
[[Category:Lymphoreticular and Haemopoietic Diseases]] | [[Category:Lymphoreticular and Haemopoietic Diseases]] | ||
Revision as of 13:20, 11 August 2010
 |
This article has been peer reviewed but is awaiting expert review. If you would like to help with this, please see more information about expert reviewing. |
| Also known as: | FIP |
Description
A progressive disease of the cat caused by feline coronavirus. FIP arises from a mutation of Feline Enteric Coronavirus (FECoV) in 5-10% of chronically infected cats and not directly from cat to cat. Two forms of the disease exist the wet or exudative form and the dry or non exudative form.
Signalment
Domestic and wild cats.
Cats compromised by immunosuppression (either iatrogenic or disease-related) are at a greater risk of developing FIP.
History and Clinical signs
FECoV may cause mild respiratory symptoms and diarrhoea but is often asymptomatic.
Signs of FIP include, chronic weight loss, anorexia, pyrexia, depression, fever and vasculitis. Fluid in the abdomen, thorax or pericardium are symptomatic of wet FIP. Granulomatous change in the organs are symptomatic of dry FIP. FIP has also been documented to cause: Uveitis, hydrocephalus, neurological symptoms, such as ataxia or seizures and chronic diarrhoea.
Diagnosis
FIP should be suspected in all cases of chronic weight loss or recurrent fever unresponsive to antibiotics, particularly in multiple cat situations. Simple serology is impossible as most cats will have antibody to FECoV.
Laboratory Tests
Four indicators can be used for diagnosis:
- High FECoV Antibody titres
- Low albumin:globulin ratio in plasma/ascites (globulin levels rise in FIP)
- High levels of glycoprotein alpha 1-acid glycoprotein (AGP)
- Low white cell counts
FIP antigen detection by immunofluorescence in macrophages gives a definite positive diagnosis
Pathogenesis
Weeks, months or years may intervene between localized primary FECoV infection and FIP development. FECoV replicates in the gut, but FIP spreads systemically in the circulation. FIP then gains the ability to replicate in monocytes and macrophages.
Failure of the immune system to clear antibody-antigen complexes leads to immune-mediated disease and deposited complexes cause inflammation and exudation. This leads to characteristic oedema as fibrin-rich serum escapes to intercellular spaces.
Pyogranulomas reactions can develop in major organs as a result of the immune response and the body's failure to clear away excess neutrophils.
Cats previously exposed to coronavirus (and therefore with circulating antibody) may be at greater risk as they are more susceptible to taking up virus into mononuclear cells.
Cats making a biased Th-1 response are more likely to evade infection, whereas cats making a balanced response are at moderate risk and cats making a biased Th-2 response are at greater risk, as the virus is best tackled by cell mediation and not antibody.
Pathology
Gross
Wet form
Widespread miliary, white, pinhead granulomas and fibrin deposition, particularly in the serosa of the small and large intestine High-protein exudates can be found in peritoneal cavity.
Dry form
Larger, grey granulomatous masses causing thickening of the wall of the small and large intestine.
Histological
Multifocal pyogranulomas on serosa and throughout gut wall. Infiltration by mononuclear cells, lymphocytes, plasma cells, macrophages and a fewneutrophils. Necrosis and vasculitis will also be seen.
Treatment
Immunomodulators including interferon have been used to control the virus and Dr. Diane Addie at Glasgow vet school has found that cats do respond to this form of treatment.
Immunosuppressive drugs such as prednisolone or cyclophosphamide may slow disease progression.
Cats should recieve widespread antibiotics and suppotive therapy.
The disease is almost invariably fatal.
Control
Conventional vaccination is counterproductive as antibody worsens infection however a non-systemic vaccine (Primucell) is available outside the UK. Replication confined to nasal mucosa, providing local immunity and cell-mediated immunity and it cannot protect cats already infected with FECoV.
Antibody tests are available to certify FECoV-free cat houses.
Prognosis
Very poor.
References
Ettinger, S.J, Feldman, E.C. (2005) Textbook of Veterinary Internal Medicine (6th edition, volume 2) W.B. Saunders Company
Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier