Difference between revisions of "B cells"

Revision as of 19:11, 25 September 2010

B Cells in Lymph node

^{©RVC 2008}

Also called B lymphocytes

So named as they were initially found in the Bursa of Fabricius. They produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes. B cells have B cell receptors (BCR), or antigen binding sites. This is IgM when the B cell is immature, changing to IgD when the cell is mature. B cells also express MHC II, CD9, CD,19, CD20 and CD24.

Under antigenic stimulation they differentiate into plasma cells and memory cells.

B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to T-cells on MHC II.

For more on B cell differentiation, see here.

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-{{OpenPagesTop}}
+[[Image:LH B cells Peyers Patch Histology.jpg|right|thumb|150px|<p>'''B Cells in Lymph node'''</p><sup>©RVC 2008</sup>]]
-[[Image:LH B cells Peyers Patch Histology.jpg|right|thumb|250px|<p>'''B Cells in Lymph node'''</p><sup>©RVC 2008</sup>]]
+''Also called B lymphocytes''
+<p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]]. They produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes.
+B cells have B cell receptors (BCR), or antigen binding sites. This is [[IgM]] when the B cell is immature, changing to [[IgD]] when the cell is mature. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p>
+<p>Under antigenic stimulation they differentiate into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p>
-Also known as '''''B lymphocytes'''''
+B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to T-cells on [[Major Histocompatability Complexes#MHC II|MHC II]].
-So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]], B cells produce antibodies and are associated with '''humoral immunity''' (T cells are part of the cell-mediated immune response), and are an integral part of the [[:Category:Adaptive Immune System|'''adaptive immune system''']]. They represent 20-30% of circulating lymphocytes.
+For more on B cell differentiation, see [[B cell differentiation|here]].
-B cells have cell surface proteins known as B cell receptors (BCRs) that are known as [[Immunoglobulins - Overview|immunoglobulins]]; [[IgM]] is the membrane bound BCR that is expressed when the B cell is immature, changing to [[IgD]] when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24.
-<p>Under antigenic stimulation B cells [[B cell differentiation|'''differentiate''']] into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p>
-B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to [[T cells]] on [[Major Histocompatability Complexes#MHC II|MHC II]].
-<br><br>
-{{Jim Bee 2007}}
-{{OpenPages}}
 [[Category:Lymphocytes|B]]

Difference between revisions of "B cells"

Revision as of 19:11, 25 September 2010

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