Difference between revisions of "B cells"
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[[Image:LH B cells Peyers Patch Histology.jpg|right|thumb|250px|<p>'''B Cells in Lymph node'''</p><sup>©RVC 2008</sup>]] | [[Image:LH B cells Peyers Patch Histology.jpg|right|thumb|250px|<p>'''B Cells in Lymph node'''</p><sup>©RVC 2008</sup>]] | ||
| − | Also known as '''''B lymphocytes | + | Also known as '''''B lymphocytes |
| − | + | <p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]], B cells produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes. | |
| − | So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]], B cells produce antibodies and are associated with | + | B cells have B cell receptors (BCRs), or antigen binding sites which combine as the antibody [[IgM]] when the B cell is immature, changing to [[IgD]] when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p> |
| − | + | <p>Under antigenic stimulation B cells differentiate into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p> | |
| − | B cells have | ||
| − | <p>Under antigenic stimulation B cells | ||
| − | B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to | + | B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to T-cells on [[Major Histocompatability Complexes#MHC II|MHC II]]. |
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[[Category:Lymphocytes|B]] | [[Category:Lymphocytes|B]] | ||
Revision as of 08:40, 27 September 2010
Also known as B lymphocytes
So named as they were initially found in the Bursa of Fabricius, B cells produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes. B cells have B cell receptors (BCRs), or antigen binding sites which combine as the antibody IgM when the B cell is immature, changing to IgD when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24.
Under antigenic stimulation B cells differentiate into plasma cells and memory cells.
B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to T-cells on MHC II.