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Endocrine Pancreas - Pathology (view source)

Revision as of 13:36, 9 June 2010

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==Neoplasia==

[[Image:Islet cell tumour.jpg|right|thumb|100px|<small><center>Islet cell tumour (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]

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===Insulin ~~secreting neoplasms~~===

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===[[Insulin Secreting Neoplasms]]===

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*Adenomas and carcinomas deerived from beta cells

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*Respond rapidly to iv glucose

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*Can be identified by immunocytochemical means

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*Dogs 5-12 years of age most commonly affected

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*Older cattle, associated with periodic convulsions

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~~====Clinical signs====~~

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*Hyperinsulinism

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*Hypoglycaemia - often episodic

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**Neurologic signs - stupor, confusion, coma, seizures, peripheral neuropathy may also develop

===Adenomas (insulinomas)===

*Usually single, or less often multiple, small (1-3cm) spherical nodule, yellow to dark red, in one or more lobes

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