Difference between revisions of "Endocrine Pancreas - Pathology"

Revision as of 13:36, 9 June 2010

Islet cell tumour (Image sourced from Bristol Biomed Image Archive with permission)

Usually single, or less often multiple, small (1-3cm) spherical nodule, yellow to dark red, in one or more lobes
Thin layer of fibrous tissue separates normal parenchyma
Small islets of acinar tissue are sometimes present within the neoplasm
Well differentiated cells

Described in dogs, cats
Known as Zollinger-Ellison syndrome in humans
Uncommon compared to beta cell neoplasms
Excess gastrin causes hyperacidity in the stomach and mucosal hyperplasia of the antral region causing gastric and duodenal ulceration

Very rare
Characterised by
- Hyperglycaemia
- Vacuolar hepatopathy
- Skin erythema with superficial necrotising dermatitis
Diagnosis in dogs is difficult as presents together with DM

@@ Line 7: / Line 7: @@
 ==Neoplasia==
 [[Image:Islet cell tumour.jpg|right|thumb|100px|<small><center>Islet cell tumour (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
-===Insulin secreting neoplasms===
+===[[Insulin Secreting Neoplasms]]===
-*Adenomas and carcinomas deerived from beta cells
-*Respond rapidly to iv glucose
-*Can be identified by immunocytochemical means
-*Dogs 5-12 years of age most commonly affected
-*Older cattle, associated with periodic convulsions
-====Clinical signs====
-*Hyperinsulinism
-*Hypoglycaemia - often episodic
-**Neurologic signs - stupor, confusion, coma, seizures, peripheral neuropathy may also develop
 ===Adenomas (insulinomas)===
 *Usually single, or less often multiple, small (1-3cm) spherical nodule, yellow to dark red,  in one or more lobes