Difference between revisions of "Lymphopenia"

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* Lymphopenia is a redcution in the numbers of lymphocytes in the blood.
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* Occurs in:
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==Description==
** Viruses that attack the lymphoid system.
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Lymphopenia is a reduction in the numbers of lymphocytes in the blood. This phenomenon is most commonly associated with stress (as part of the '''stress leucogram''') or with viral infection. Its causes therefore include:
*** For example:
 
**** [[Paramyxoviridae#Canine Distemper Virus (CDV)|Canine Distemper]]
 
**** Infectious Canine Hepatitis
 
**** Feline Infectious Enteritis
 
**** Bovine Virus Diarrhoea.
 
** Irradiation
 
** Corticosteroid therapy.
 
*** Selectively suppresses lymphocytic activity, and the inflammatory response in general.
 
  
*** Other immunosuppressive drugs may act in a similar way.
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*Viral infection
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**[[Paramyxoviridae#Canine Distemper Virus (CDV)|Canine Distemper]]
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**Infectious Canine Hepatitis
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**Feline Infectious Enteritis
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**Bovine Viral Diarrhoea (BVD)
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*Bone marrow suppression caused by '''chemotherapy''' or '''radiotherapy'''.  Since neutrophils have a much shorter circulating half life, they are the first cell line to fall with any insult to the bone marrow but lymphopenia may occur as part of a more severe pancytopenia.
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*Inherited or acquired immunodeficiency syndromes, including '''SCID''' (Severe Combined Immunodeficiency Syndrome) in Arab foals and [[Feline Immunodeficiency Virus|'''FIV''']] infection.
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*Stress leucogram, characterised by '''neutrophilia''', '''monocytosis''', '''eosinopenia''' and '''lymphopenia'''.  A similar pattern may occur with hyperadrenocorticism (Cushing’s disease) or exogenous corticosteroid therapy as these hormones selectively suppress lymphocytic activity and the inflammatory response in general.  Young horses may develop lymphopenia when exposed to even mild stress, such as handling.
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*Leakage of lymphatic fluid may result in loss of lymphocytes, as with '''[[Lymphangiectasia|lymphangiectasia]]''' or '''[[Chylous Effusions|chylothorax]]'''.
  
 
[[Category:Haematology Changes]][[Category:To Do - James]]
 
[[Category:Haematology Changes]][[Category:To Do - James]]

Revision as of 13:13, 30 August 2010



Description

Lymphopenia is a reduction in the numbers of lymphocytes in the blood. This phenomenon is most commonly associated with stress (as part of the stress leucogram) or with viral infection. Its causes therefore include:

  • Viral infection
    • Canine Distemper
    • Infectious Canine Hepatitis
    • Feline Infectious Enteritis
    • Bovine Viral Diarrhoea (BVD)
  • Bone marrow suppression caused by chemotherapy or radiotherapy. Since neutrophils have a much shorter circulating half life, they are the first cell line to fall with any insult to the bone marrow but lymphopenia may occur as part of a more severe pancytopenia.
  • Inherited or acquired immunodeficiency syndromes, including SCID (Severe Combined Immunodeficiency Syndrome) in Arab foals and FIV infection.
  • Stress leucogram, characterised by neutrophilia, monocytosis, eosinopenia and lymphopenia. A similar pattern may occur with hyperadrenocorticism (Cushing’s disease) or exogenous corticosteroid therapy as these hormones selectively suppress lymphocytic activity and the inflammatory response in general. Young horses may develop lymphopenia when exposed to even mild stress, such as handling.
  • Leakage of lymphatic fluid may result in loss of lymphocytes, as with lymphangiectasia or chylothorax.