Difference between revisions of "B cells"
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| − | [[Image:LH B cells Peyers Patch Histology.jpg|right|thumb| | + | [[Image:LH B cells Peyers Patch Histology.jpg|right|thumb|250px|<p>'''B Cells in Lymph node'''</p><sup>©RVC 2008</sup>]] |
| − | '' | + | Also known as '''''B lymphocytes |
<p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]]. They produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes. | <p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]]. They produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes. | ||
B cells have B cell receptors (BCR), or antigen binding sites. This is [[IgM]] when the B cell is immature, changing to [[IgD]] when the cell is mature. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p> | B cells have B cell receptors (BCR), or antigen binding sites. This is [[IgM]] when the B cell is immature, changing to [[IgD]] when the cell is mature. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p> | ||
Revision as of 08:28, 27 September 2010
Also known as B lymphocytes
So named as they were initially found in the Bursa of Fabricius. They produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes. B cells have B cell receptors (BCR), or antigen binding sites. This is IgM when the B cell is immature, changing to IgD when the cell is mature. B cells also express MHC II, CD9, CD,19, CD20 and CD24.
Under antigenic stimulation they differentiate into plasma cells and memory cells.
B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to T-cells on MHC II.
For more on B cell differentiation, see here.