Difference between revisions of "Porcine Adenovirus"
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| − | Also Known As | + | Also Known As: '''''pADV 1-5 — pADV A-C''''' |
==Introduction== | ==Introduction== | ||
| − | Porcine adenovirus causes [[Diarrhoea|diarrhoea]] and | + | Porcine adenovirus causes [[Diarrhoea|diarrhoea]] and gastrointestinal disease in piglets and also often being implicated in '''multifactorial respiratory''' diseases. |
pADV-4 is thought to be the most pathogenic of the porcine [[Adenoviridae|adenoviruses]]. | pADV-4 is thought to be the most pathogenic of the porcine [[Adenoviridae|adenoviruses]]. | ||
| Line 23: | Line 23: | ||
'''Reproductive''' disease may present as abortion and stillbirth pigs. | '''Reproductive''' disease may present as abortion and stillbirth pigs. | ||
| − | Respiratory disease, e.g. cough, dyspnoea, blue extremities etc often develops when combined with other pathogens. | + | Respiratory disease, e.g. cough, dyspnoea, blue extremities etc. often develops when combined with other pathogens. |
Subclinical and asymptomatic infections are common. | Subclinical and asymptomatic infections are common. | ||
==Diagnosis== | ==Diagnosis== | ||
| − | Histologically, pADV causes formation of '''nuclear inclusion bodies''' in the intestinal cells<ref> Buller, C. R., Moxley, R. A. (1988) Natural infection of porcine ileal dome M cells with rotavirus and enteric adenovirus. Vet Path, 25(6):516-517; 9</ref>. | + | Histologically, pADV causes formation of '''nuclear inclusion bodies''' in the intestinal cells<ref> Buller, C. R., Moxley, R. A. (1988) '''Natural infection of porcine ileal dome M cells with rotavirus and enteric adenovirus.''''' Vet Path'', 25(6):516-517; 9</ref>. |
'''Viral isolation can be performed in tissue cultures'''. Cells infected become rounded and enlarged and then detach from the vessel. | '''Viral isolation can be performed in tissue cultures'''. Cells infected become rounded and enlarged and then detach from the vessel. | ||
| Line 34: | Line 34: | ||
Viral particles can be seen via '''electron microscopy''' up to 6 days post infection. | Viral particles can be seen via '''electron microscopy''' up to 6 days post infection. | ||
| − | '''Immunoperoxidase and immunofluorescent''' staining can demonstrate viral antigen. | + | '''Immunoperoxidase and [[Immunofluorescence|immunofluorescent]]''' staining can demonstrate viral antigen. |
| − | '''Antibodies''' can be detected serologically with '''immunodiffusion, complement fixation, serum neutralisation and [[ELISA testing|ELISA]].''' | + | '''Antibodies''' can be detected serologically with '''[[immunodiffusion]], [[Complement Fixation|complement fixation]], serum neutralisation and [[ELISA testing|ELISA]].''' |
==Treatment== | ==Treatment== | ||
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==Control== | ==Control== | ||
| − | '''None''' is usually practised although a study has demonstrated beneficial use of a vaccine<ref> Kadoi, K (1997) Beneficial use of inactivated porcine adenovirus vaccine and antibody response of young pigs. New Microbiol. 20:89-91</ref> | + | '''None''' is usually practised although a study has demonstrated beneficial use of a vaccine<ref> Kadoi, K (1997) '''Beneficial use of inactivated porcine adenovirus vaccine and antibody response of young pigs.''''' New Microbiol''. 20:89-91</ref> |
{{Learning | {{Learning | ||
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Animal Health & Production Compendium, '''Porcine Adenovirus infection datasheet''', accessed 16/06/2011 @ http://www.cabi.org/ahpc/ | Animal Health & Production Compendium, '''Porcine Adenovirus infection datasheet''', accessed 16/06/2011 @ http://www.cabi.org/ahpc/ | ||
| − | [[Category: | + | |
| + | {{review}} | ||
| + | [[Category:Adenoviridae]] | ||
| + | [[Category:Gastric Diseases - Pig]][[Category:Intestinal Diseases - Pig]] | ||
| + | [[Category:Respiratory Diseases - Pig]] | ||
| + | [[Category:Reproductive Diseases - Pig]] | ||
| + | [[Category:Pig Viruses]] | ||
| + | [[Category:CABI Expert Review]] | ||
Revision as of 22:48, 5 July 2011
Also Known As: pADV 1-5 — pADV A-C
Introduction
Porcine adenovirus causes diarrhoea and gastrointestinal disease in piglets and also often being implicated in multifactorial respiratory diseases.
pADV-4 is thought to be the most pathogenic of the porcine adenoviruses.
Distribution
Worldwide
Transmission is faecal:oral
Signalment
pADV is only known to affect swine.
Clinical Signs
pADV is a low grade pathogen, associated with short duration mild clinical signs.
Diarrhoea, inappetance, dehydration and anorexia often present in various degrees of severity.
Dullness, depression, lethargy, listlessness and tremors may develop, often secondary to dehydration.
Reproductive disease may present as abortion and stillbirth pigs.
Respiratory disease, e.g. cough, dyspnoea, blue extremities etc. often develops when combined with other pathogens.
Subclinical and asymptomatic infections are common.
Diagnosis
Histologically, pADV causes formation of nuclear inclusion bodies in the intestinal cells[1].
Viral isolation can be performed in tissue cultures. Cells infected become rounded and enlarged and then detach from the vessel.
Viral particles can be seen via electron microscopy up to 6 days post infection.
Immunoperoxidase and immunofluorescent staining can demonstrate viral antigen.
Antibodies can be detected serologically with immunodiffusion, complement fixation, serum neutralisation and ELISA.
Treatment
None is usually necessary as disease is mild and/or transient.
Control
None is usually practised although a study has demonstrated beneficial use of a vaccine[2]
| Porcine Adenovirus Learning Resources | |
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 Test your knowledge using flashcard type questions |
Porcine Adenovirus Flashcards |
References
Animal Health & Production Compendium, Porcine Adenovirus datasheet, accessed 16/06/2011 @ http://www.cabi.org/ahpc/
Animal Health & Production Compendium, Porcine Adenovirus infection datasheet, accessed 16/06/2011 @ http://www.cabi.org/ahpc/
 |
This article has been peer reviewed but is awaiting expert review. If you would like to help with this, please see more information about expert reviewing. |